Coluracetam
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||||||||||||||
| Common names | Coluracetam | ||||||||||||||||||||||||||||||||||||||||||||
| Systematic name | N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide | ||||||||||||||||||||||||||||||||||||||||||||
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| Psychoactive class | Nootropic | ||||||||||||||||||||||||||||||||||||||||||||
| Chemical class | Racetam | ||||||||||||||||||||||||||||||||||||||||||||
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| Summary sheet: Coluracetam |
Coluracetam (BCI-540), formerly (MKC-231) is a racetam promoted as a nootropic with action upon the high affinity choline uptake. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. It is readily available and sold through online vendors as a dietary supplement in the U.S. To supplement coluracetam, one should take 5 – 20 mg at once. Dosages range nearly half of that of noopept, making it twice as potent while offering comparable benefit. Due to it's short acting and acute nature, the preferred ROA is generally insufflation, sublingual, or vaporising, though it is still active orally.
This compound's active dose range is between 5 and 20 mg. This is much smaller than the comparative doses of the racetam class of drugs (piracetam, oxiracetam, phenylpiracetam, etc.) Dosages higher than 20mg do not appear to offer any additional benefit.
Chemistry
Coluracetam, or 2-(2-oxopyrrolidin-1-yl)-N-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro2, 3-b quinolin-4-yl)acetoamide, is a synthetic racetam. A known metabolite is hydroxylated coluracetam on the 2-carbon of the pyrrolidinone backbone, it is sometimes referred to as M-MKC-231. It appears inactive on the main mechanism of action coluracetam is known for (increasing HACU).
Pharmacology
Coluracetam has been detected in plasma following oral ingestion, and appears to be able to reach high levels within 30 minutes and is already on the decline within 3 hours. Supplementation of coluracetam for 7-14 days does not alter these kinetics, so may demonstrate resistance to tolerance build-up.
However, the role of these interactions and how they result in the compound's effects continues to remain elusive.
Subjective effects
Chief amongst Coluracetam's effects is it's ability to enhance the immediate five senses, promoting a heightened awareness of ones surroundings as well as a sense of awareness of oneself within it. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Visual effects
- Acuity enhancement - Most prominent for most users is coluracetam's visual effects, users describing it as "widescreen HD vision."
- Colour enhancement - Coluracetam has been described to make colours appear more vibrant.
- Auditory enhancement - Some users describe a better and crisper perception of sounds.
- Mindfulness - Coluracetam can invoke the first component of mindfulness, or an enhanced perception of immediate environment, while being remaining absent of mindfulness's second component.
- Tactile enhancement - Coluracetam may promote a heightened awareness of textures of objects as well as the sensations of the body.
- [[Effect::Brightness alteration] - Secondary to color enhancement, users may feel an enhanced sense of brightness of scenery.
Physical effects
- Stimulation - The stimulation which Coluracetam presents can be considered as primarily subtle and short lasting, comparable to that of caffeine.
Cognitive effect
- Thought deceleration - Coluracetam's effects may promote an acute one's thoughts taking a backseat to their heightened sense of presence.
- Cognitive euphoria
- Wakefulness
- Thought connectivity
- Focus enhancement
- Motivation enhancement
- Memory enhancement
- Rejuvenation
- Anxiety suppression
- Irritability
Toxicity and harm potential
There are no known long-term dangers or health safety issues. However, there are a small number of people who suffer from nausea, depression, and the inability to sleep. It is recommended to cease usage immediately if these side effects are experienced.
Lethal dosage
The median lethal dosage (LD50) of coluracetam has not been officially published as it has low abuse potential, but the recommended dosage is 10mg once to three times a day. Anecdotal evidence from people within the community who have tried coluracetam suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but, as per most substances, nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
There is a slight tolerance with coluracetam which builds up with repeated usage, though preliminary reports may demonstrate a lasting promotion of efficient Cholinergic Neurotransmission, promoting a downregulation of a rate-limiting step of acetylcholine synthesis. There does not seem to be any addictive potential.
Legal issues
Coluractam, being a member of the racetam family, currently is legally available to buy and sell in most countries, but may still vary by region.
See also
External links
References
Takashina K, et al MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake . J Neural Transm. (2008) Bessho T, et al MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats . J Neural Transm. (2008)