4-HO-DET

4-HO-DET
Chemical Nomenclature
Common names	DiPT
Substitutive name	N,N-Diisopropyltryptamine
Systematic name	3-[2-(Diisopropylamino)ethyl]indole
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Smoked Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 20 mg Strong 20 - 30 mg Heavy 30 mg + Duration Total 15 - 60 minutes Onset 5 - 15 minutes ⇣ Oral Dosage Threshold 15 mg Light 15 - 30 mg Common 30 - 75 mg Strong 75 - 150 mg Heavy 150 mg + Duration Total 3 - 26 hours Onset 30 - 60 minutes Offset 2 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

4-HO-DET also known as 4-hydroxy-diethyl-tryptamine, CZ-74, or ethocin is a hallucinogenic psychedelic drug of the tryptamine family.

This compound was first discovered in the late 1950s by Albert Hofmann and Franz Troxler. The substance was used together with its phosphoryloxy-analog 4-PO-DET in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.

Today it is used as a recreational or entheogenic compound through the use of online research chemical vendors. However, it remains relatively uncommon and has very little history of human usage.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

Main article: Serotonergic psychedelic

4-HO-DET acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-HO-DET's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of 4-HO-DET can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations
• Nausea
• Tactile enhancement
• Bodily control enhancement
• Increased heart rate
• Pupil dilation

Cognitive effects

The cognitive effects of 4-HO-DET can be broken down into several components which progressively intensify proportional to dosage.

The most prominent of these cognitive effects generally include:

• Current mind state enhancement
• Thought acceleration
• Novelty enhancement
• Immersion enhancement
• Time distortion
• Analysis enhancement
• Personal bias suppression
• Conceptual thinking
• Memory suppression
  • Ego death
• Mindfulness
• Thought loops
• Delusions
• Unity and interconnectedness
• Spirituality enhancement
• Thought disorganization
• Wakefulness
• Creativity enhancement

Visual effects

Enhancements

4-HO-DET presents a full and complete array of visual enhancements which generally includes:

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

4-HO-DET presents a full and complete array of visual distortions which generally includes:

• Drifting (melting, breathing, morphing and flowing)
• Tracers
• Depth perception distortions
• Symmetrical texture repetition
• Colour shifting
• Perspective distortions

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

The auditory effects of 4-HO-DET are common in their occurrence and exhibit a full range of effects which commonly includes:

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychedelic community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Tolerance and addiction potential

4-HO-DET is non-habit forming and the desire to use it can actually decrease with use. It is most often self-regulating.

An almost immediate tolerance is built to 4-HO-DET after ingestion, preventing one from experiencing its full effects more often than every 4-7 days unless they increase their dose significantly.

Legal issues

• Sweden - 4-HO-DET is classified as a "health hazard" under the Act on the Prohibition of Certain Goods Dangerous to Health as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-dietyltryptamin (4-HO-DET), making it illegal to sell or possess.

See also

• 4-HO-DET (wikipedia)
• 4-HO-DET (TiHKAL)
• 4-AcO-DET degradation (erowid)
• Tryptamine
• Psychedelic