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Talk:Xylazine
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Xylazine (also known as xyl, xyla, or tranq) is a central nervous system (CNS) depressant substance of the imidazoline class. It is primarily used as an anaesthetic in combination with ketamine or as an emetic (to induce vomiting) in veterinary medicine.
Xylazine is often used as a cutting agent for other sedative street drugs, such as ketamine, fentanyl, and others, leading to many medical complications and deaths for drug users. Fentanyl mixed with xylazine is sometimes known as "sleep-cut", "zombie", and "tranq dope" and is often fatal.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
Xylazine was discovered in 1962 to treat hypertension in veterinary medicine. Studies in humans found it to be a dangerous central nervous system depressant with hazardous side effects and the drug was never approved by the FDA for human use.
The drug is often diverted from veterinarians and used as a cutting agent to make street drugs appear stronger, .
Clonidine, or 2-[(2,6-Dichlorophenyl)imino]imidazoline, is a compound of the imidazoline chemical class. Imidazolines are substituted amidines in which the amidine function is incorporated into an imidazoline ring
Xylazine is structurally similar to clonidine and an agonist for the α2adrenergicreceptor. When α2 receptors in the brain are stimulated, peripheral vascular resistance decreases, resulting in lowered blood pressure. It has specificity towards the presynaptic α2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic nervous system tone.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
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Sedation - Xylazine is extremely sedating and will most likely put the user to sleep before any enjoyable effects are experienced. Users may not wake up until the effects of the drug wears off.
Dizziness - This effect can increase the likelihood of falling and injuring oneself.
Spontaneous bodily sensation - Reduced blood flow to the limbs and extremeties may cause a tingling sensation, similar to a "dead leg" after sitting in a strange position for too long
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Visual effects
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There are currently 0 experience reports which describe the effects of this substance in our experience index. Additional experience reports can be found here:
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Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
Xylazine has little or no recreational benefit and is can be very dangerous dangerous for the user and has resulted in numerous deaths. Usage may lead to dependence, diabetes, heart complications, loss of muscle mass, and hyperglycemia. Injection sites may quickly deteriorate, develop necrosis, develop ulcers, develop abscesses and/or become infected. This decomposition is extremely painful and may have a foul odour, in severe cases amputation may be necessary.[citation needed]
Overdose is often irreversible and fatal in humans. Naloxone will not reverse a xylazine overdose but should still be administered incase of presence of fentanyl. Xylazine can cause toxicity and death in humans at dosages ranging from 40 to 2400 mg[1]
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants - Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.
