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Eugeroics
Eugeroics (originally, "eugrégorique" or "eugregoric"), also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness. They are medically indicated for the treatment of certain sleep disorders including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA). They generally have a very low addictive potential. Eugeroics are also often prescribed off-label for the treatment of EDS in idiopathic hypersomnia, a rare and often debilitating sleep disorder which currently has no official treatments approved by the Food and Drug Administration (FDA).
Examples
Marketed
- Armodafinil (Nuvigil)
- Modafinil (Provigil)
- Solriamfetol (Sunosi)
- Pitolisant (Wakix)
Discontinued
Never marketed
- Flmodafinil (CRL-40,940)
- Fluorafinil (CRL-40,941)
- Fluorenol
- Methylbisfluoromodafinil
In development
- Selective H3 receptor antagonists/inverse agonists
- Selective orexin receptor agonists