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Talk:Clozapine
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Revision as of 13:51, 13 July 2017 by >Corticosteroid(Added to tox&harm potential. The addition is about neuroleptic malignant syndrome, a dangerous condition that can be caused by antipsychotics like clozapine.)
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Clozapine (trade names Clozaril and FazaClo) is an atypical antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Therefore, it is a drug of last resort (DoLR).
Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
Cloazapine classified as an atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. It is a serotonin antagonist, with strong binding to the 5-HT2A and 5-HT2C receptor subtypes.
It also displays a strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, which is commonly thought to modulate neuroleptic activity.
Agranulocytosis (severely low white blood cell count) is a major adverse effect associated with the administration of this agent.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Clozapine can cause agranulocytosis as mentioned before, and therefore lower doses and self-monitoring for this condition are ideal. Clozapine can be dispensed by prescription, and if you already have a prescription, you should know your blood test results of red, amber, or green. You should not accept clozapine from people or sources you do not trust, and this goes the same for any other drug. Clozapine can also cause NMS, or neuroleptic malignant syndrome. This reaction is rare, but serious and includes dysfunctions such as muscle rigidity, hyperthermia, paleness, psychomotor agitation, respiratory distress (tachypnea), and more. Tripsitters should be used and, once again, low doses should be started with.
As such, it may contain incomplete or wrong information. You can help by expanding it.
United States: Clozapine is not a controlled substance, but is a prescription-only medicine. Bloodwork for a condition called agranulocytosis is often done for safety before prescribing.
Australia: Clozapine is a schedule four substance, meaning it is a prescription-only medicine.
