Dangerous combinations
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Although most drugs are safe to use when the user has good knowledge of a proper dosage, sometimes when two or more drugs are consumed at the same time, the unwanted consequences can be dangerous or even fatal.
Most commonly drug related deaths occur when combining depressants. Depressants affect parts of the brain and neurotransmitters responsible for respiration, and an overdose or combination of these drugs can result in fatal levels of respiratory depression, or death may occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit.
Another possibly fatal combination of drugs are serotonergic substances, which might cause serotonin syndrome. This can also be caused alone by an overdose of said substances. Serotonin syndrome is a result of excess serotonin in the brain, which can cause seizures, anxiety, tremors, nausea, coma and possibly a deadly level of fever. Usually this is caused when an user has used an antidepressant within the last 2 weeks of consuming said drug. These kind of antidepressants include monoamine oxidase inhibitors, serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors.
Depressants
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Serotonergic drugs
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Other
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