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Template:Peganum harmala alkaloids: Difference between revisions

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Revision as of 02:02, 16 July 2021

Alkaloid Content Type
Desoxypeganine[1] MAO-A[2]
Harmalicidine[3]
Harmaline (harmidine) 0.25%[4]–0.79%[5]–5.6%[6] Reversible inhibitor of monoamine oxidase A (RIMA)
Harmalol 0.6%[6]–3.90%[4]
Harmane (harman) 0.16%[4] MAO-A and MAO B[7]
Harmine (banisterine, telepathine) 0.44%[5]–1.84%[4]–4.3%[6] – The coatings of the seeds are said to contain large amounts of harmine.[8] Reversible inhibitor of monoamine oxidase A (RIMA)
Tetrahydroharmine (THH) 0.1%[6] Serotonine reuptake inhibitor[9]
Vasicine (peganine)[10] 0.25%[5]
Vasicinone[10] 0.0007%[5]
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841998/
  2. Algorta, J; Pena, MA; Maraschiello, C; Alvarez-González, A; Maruhn, D; Windisch, M; Mucke, HA (March 2008). "Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses". Methods and findings in experimental and clinical pharmacology. 30 (2): 141–7. doi:10.1358/mf.2008.30.2.1159649. PMID 18560630. 
  3. Lamchouri, F; Zemzami, M; Jossang, A; Abdellatif, A; Israili, ZH; Lyoussi, B (July 2013). "Cytotoxicity of alkaloids isolated from Peganum harmala seeds". Pakistan journal of pharmaceutical sciences. 26 (4): 699–706. PMID 23811445. 
  4. 4.0 4.1 4.2 4.3 Hemmateenejad B, Abbaspour A, Maghami H, Miri R, Panjehshahin MR (August 2006). "Partial least squares-based multivariate spectral calibration method for simultaneous determination of beta-carboline derivatives in Peganum harmala seed extracts". Anal. Chim. Acta. 575 (2): 290–9. doi:10.1016/j.aca.2006.05.093. PMID 17723604. 
  5. 5.0 5.1 5.2 5.3 Pulpati H, Biradar YS, Rajani M (2008). "High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala". J AOAC Int. 91 (5): 1179–85. doi:10.1093/jaoac/91.5.1179Freely accessible. PMID 18980138. 
  6. 6.0 6.1 6.2 6.3 Herraiz T, González D, Ancín-Azpilicueta C, Arán VJ, Guillén H (March 2010). "beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)". Food Chem. Toxicol. 48 (3): 839–45. doi:10.1016/j.fct.2009.12.019. PMID 20036304. 
  7. Herraiz, T; Chaparro, C (18 January 2006). "Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee". Life sciences. 78 (8): 795–802. doi:10.1016/j.lfs.2005.05.074. PMID 16139309. 
  8. Cite error: Invalid <ref> tag; no text was provided for refs named cdfa
  9. Callaway, James C.; McKenna, Dennis; Grob, Charles S.; et al. (June 1999). "Pharmacokinetics of hoasca alkaloids in healthy humans". Journal of Ethnopharmacology. 65 (3): 243–56. doi:10.1016/S0378-8741(98)00168-8. ISSN 0279-1072. PMID 10404423. 
  10. 10.0 10.1 Cite error: Invalid <ref> tag; no text was provided for refs named nook