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Yohimbine hydrochloride (also known as quebrachine) is a naturally-occurringstimulant substance derived from the bark of the African tree Pausinystalia johimbe. Yohimbine is the major active constituent of the bark, with the active ingredient being yohimbine hydrochloride. It is commonly used as a fat-burning compound or for to treatment of erectile dysfunction.
Yohimbine is a drug used in veterinary medicine to reverse the effects of xylazine (Wikipedia) in dogs and deer. It is used as a research reagent. In the US it is prescribed, but now rarely, for erectile dysfunction in men.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - Stimulation is especially noticeable once you begin an activity that increase adrenaline output, such as training or intake of another stimulant like caffeine.
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
↑Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/7557820
↑Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/9004342
