Coluracetam

Coluracetam
Chemical Nomenclature
Common names	Coluracetam
Systematic name	N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide
Class Membership
Psychoactive class	Nootropic
Chemical class	Racetam
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 1 mg Light 3 - 5 mg Common 5 - 10 mg Strong 10 - 20 mg Heavy 20 mg + Duration Total 3 - 6 hours Onset 15 - 30 minutes ⇣ Insufflated Dosage Threshold 1 mg Light 2 - 5 mg Common 5 - 10 mg Strong 10 - 20 mg Heavy 20 mg + Duration Total 3 - 6 hours Onset 1 - 5 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Stimulants
Depressants
Dissociatives

Summary sheet: Coluracetam

Coluracetam (BCI-540), formerly (MKC-231) is a nootropic of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid major depressive disorder (MDD) with generalized anxiety disorder (GAD).

It is readily available and sold through online vendors as a dietary supplement in the U.S. To supplement coluracetam, one should take 5 – 20 mg at once. Dosages range nearly half of that of noopept, making it twice as potent while offering comparable benefit. Due to it's short acting and acute nature, the preferred ROA is generally insufflation, sublingual, or vaporising, though it is still active orally.

This compound's active dose range is between 5 and 20 mg. This is much smaller than the comparative doses of the racetam class of drugs (piracetam, oxiracetam, phenylpiracetam, etc.) Dosages higher than 20mg do not appear to offer any additional benefit.

Chemistry

Coluracetam, or 2-(2-oxopyrrolidin-1-yl)-N-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro2, 3-b quinolin-4-yl)acetoamide, is a synthetic racetam. A known metabolite is hydroxylated coluracetam on the 2-carbon of the pyrrolidinone backbone, it is sometimes referred to as M-MKC-231. It appears inactive on the main mechanism of action coluracetam is known for (increasing HACU).

Pharmacology

Coluracetam enhances high-affinity choline uptake (HACU), which is the rate-limiting step of acetylcholine (ACh) synthesis.

However, the role of these interactions and how they result in the compound's effects continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Sensory effects

A prominent experience amongst Coluracetam's effects is it's ability to enhance the immediate five senses.

• Acuity enhancement - Most prominent for most users is coluracetam's visual effects, users describing it as "widescreen HD vision."
• Colour enhancement - Coluracetam has been described to make colours appear more vibrant.
• Auditory enhancement - Some users describe a better and crisper perception of sounds.
• Mindfulness - Coluracetam can invoke the first component of mindfulness, or an enhanced perception of immediate environment, while being remaining absent of mindfulness's second component.
• Tactile enhancement - Coluracetam may promote a heightened awareness of textures of objects as well as the sensations of the body.
• Brightness alteration - Secondary to color enhancement, users may feel an enhanced sense of brightness of scenery.

Physical effects

• Stimulation - The stimulation which Coluracetam presents can be considered as primarily subtle and short lasting, comparable to that of caffeine.

Cognitive effect

• Cognitive euphoria
• Wakefulness
• Thought connectivity
• Focus enhancement
• Motivation enhancement
• Memory enhancement
• Rejuvenation
• Anxiety suppression
• Irritability

Toxicity and harm potential

There are no known long-term dangers or health safety issues. However, there are a small number of people who suffer from nausea, depression, and the inability to sleep. It is recommended to cease usage immediately if these side effects are experienced.

Lethal dosage

The median lethal dosage (LD50) of coluracetam has not been officially published as it has low abuse potential, but the recommended dosage is 10mg once to three times a day. Anecdotal evidence from people within the community who have tried coluracetam suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but, as per most substances, nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

There is a slight tolerance with coluracetam which builds up with repeated usage, though preliminary reports may demonstrate a lasting promotion of efficient Cholinergic Neurotransmission, promoting a downregulation of a rate-limiting step of acetylcholine synthesis. There does not seem to be any addictive potential.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

Coluractam, being a member of the racetam family, currently is legally available to buy and sell in most countries, but may still vary by region.

See also

• Responsible use
• Noopept
• Nootropic
• Stimulant
• Modafinil

External links

• Coluracetam (Wikipedia)
• Coluracetam (TripSit)
• Coluracetam (Examine)