Talk:Xylazine

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Xylazine Chemical Nomenclature Common names common name::Xyl, common name::Xyla, common name::Zine, common name: Tranq, common name::Zombie, common name::Rompun, common name::Anased, common name::Sedazine, common name::Chanazine Substitutive name Xylazine Systematic name N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine Class Membership Psychoactive class psychoactive class::Depressant Chemical class chemical class::Imidazoline Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral Dosage Threshold Oral threshold dose::x Oral dose units::mg Light Oral min light dose::x - Oral max light dose::x mg Common Oral min common dose::x - Oral max common dose::x μg Strong Oral min strong dose::x - Oral max strong dose::x mg Heavy Oral heavy dose::15 mg + Duration Total Oral min total time::y - Oral max total time::y Oral total time units::hours Onset Oral min onset time::y - Oral max onset time::y Oral onset time units::minutes Peak Oral min peak time::y - Oral max peak time::y Oral peak time units::minutes Offset Oral min offset time::y - Oral max offset time::y Oral offset time units::hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions Stimulants Depressants Dissociatives

Xylazine (also known as xyl, xyla, or tranq) is a psychoactive class::depressant substance of the chemical class::imidazoline class. It is primarily used as an anaesthetic in combination with ketamine or as an emetic (to induce vomiting) in veterinary medicine.

Xylazine is often used as a cutting agent for other sedative street drugs, such as ketamine, fentanyl, and others, leading to many medical complications and deaths for drug users. Fentanyl mixed with xylazine is known as "sleep-cut", "zombie", and "tranq dope"

History and culture

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Chemistry

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Pharmacology

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Subjective effects This subjective effects section is a stub.

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects If applicable, a brief paragraph summary of the substance's physical effects may be included here. You may select physical effects to add below here. Sedation Respiratory depression Decreased heart rate Decreased blood pressure Pain relief Visual effects If applicable, a brief paragraph summary of the substance's visual effects may be included here. You may select visual effects to add below here. Enhancements Effect::Visual acuity effect1 Distortions Effect::Visual distortion effect1 Effect::Geometry

If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.

Hallucinatory states

If applicable, a brief summary of the substance's visual effects profile may be written here.

Effect::Hallucinatory states1 Cognitive effects If applicable, a brief paragraph summary of the substance's cognitive effects may be included here. You may select from a list of cognitive effects to add below here. Irritability Effect::Cognitive effect2 Effect::Cognitive effect3 Auditory effects If applicable, a brief paragraph summary of the substance's auditory effects may be included here. You may select from a list of auditory effects to add below here. Effect::Auditory effect1 Effect::Auditory effect2 Multi-sensory effects If applicable, a brief paragraph summary of the substance's multisensory effects may be included here. You may select from a list of multisensory effects to add below here. Effect::Multisensory effect1 Effect::Multisensory effect2 Transpersonal effects If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here. You may select from a list of transpersonal effects to add below here. Effect::Transpersonal effect1 Effect::Transpersonal effect2 Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.   Additional experience reports can be found here:

t  Toxicity and harm potential

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Xylazine has little or no recreational benefit and is can be very dangerous dangerous for the user and has resulted in numerous deaths. Usage may lead to dependence, diabetes, heart complications, loss of muscle mass, and hyperglycemia. Injection sites may quickly deteriorate, develop necrosis, develop ulcers, develop abscesses and/or become infected. This decomposition is extremely painful and may have a foul odour, in severe cases amputation may be necessary. [citation needed]

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Overdose is often irreversible and fatal in humans. Naloxone will not reverse a xylazine overdose but should still be administered incase of presence of fentanyl. Xylazine can cause toxicity and death in humans at dosages ranging from 40 to 2400 mg

Tolerance and addiction potential Dangerous interactions

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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Depressants (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB/GBL, methaqualone, opioids) - This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit while unconscious. If nausea or vomiting occurs before a loss of consciousness, users should attempt to fall asleep in the recovery position or have a friend move them into it. Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it. Stimulants - Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached. Legal status

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Austria: Australia: Canada: Germany: Netherlands: Russia: Switzerland: Turkey: United Kingdom: United States: See also Responsible use Volumetric liquid dosing Fentanyl External links

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Xylazine (Wikipedia) Xylazine (Erowid Vault) Literature APA formatted reference

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References

https://www.ncbi.nlm.nih.gov/books/NBK594271/