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>Xbdab
Dosages and Durations start
>Xbdab
Updated SubstanceBox
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     <!-- Structure -->
     <!-- Structure -->
     |MolecularStructureCaption=
     |MolecularStructureCaption=
     |SkeletalImageFile=File:Phenylephrine.svg
     |SkeletalImageFile=File:Phenylephrine_Structural_Formula_V1.svg
     |3DImageFile=
     |3DImageFile=
     |3DImageWidth=
     |3DImageWidth=
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     <!-- Nomenclature -->
     <!-- Nomenclature -->
     |NameCommon=Phenylephrine
     |NameCommon=Phenylephrine
     |NameSubstitution=Neo-synephrine, others
     |NameSubstitution=Neo-synephrine, m-Synephrine, β-HO-N-Me-3-HPEA
     |NameSystematic=3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
     |NameSystematic=3-[1-Hydroxy-2-(methylamino)ethyl]phenol


     <!-- Class Membership -->
     <!-- Class Membership -->
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     |OralROA=true
     |OralROA=true
     |OralROA_Collapsed=false
     |OralROA_Collapsed=true
     |OralROA_Caption=
     |OralROA_Caption=
     |OralROA_Bioavailability=[[Oral min bioavailability::38]]% - [[Oral max bioavailability::38]]%
     |OralROA_Bioavailability=[[Oral min bioavailability::38]]% - [[Oral max bioavailability::38]]%
     |OralROA_Microdose=
     |OralROA_Microdose=
     |OralROA_Threshold=[[Oral threshold dose::5]] -  [[Oral dose units::mg]]  
     |OralROA_Threshold=[[Oral threshold dose::3]] -  [[Oral dose units::mg]]  
     |OralROA_Light=[[Oral min light dose::x]] - [[Oral max light dose::y]] mg
     |OralROA_Light=[[Oral min light dose::5]] - [[Oral max light dose::9]] mg
     |OralROA_Common=[[Oral min common dose::x]] - [[Oral max common dose::y]] mg
     |OralROA_Common=[[Oral min common dose::10]] - [[Oral max common dose::y]] mg
     |OralROA_Strong=[[Oral min strong dose::x]] - [[Oral max strong dose::y]] mg
     |OralROA_Strong=[[Oral min strong dose::x]] - [[Oral max strong dose::59]] mg
     |OralROA_Heavy=[[Oral heavy dose::x]] mg +
     |OralROA_Heavy=[[Oral heavy dose::60]] mg +
     |OralROA_TimelineFile=
     |OralROA_TimelineFile=
     |OralROA_TimelineWidth=
     |OralROA_TimelineWidth=
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     |OralROA_Offset=[[Oral min offset time::x]] - [[Oral max offset time::y]] [[Oral offset time units::hours]]
     |OralROA_Offset=[[Oral min offset time::x]] - [[Oral max offset time::y]] [[Oral offset time units::hours]]
     |OralROA_Aftereffects=[[Oral min afterglow time::x]] - [[Oral max afterglow time::y]] [[Oral afterglow time units::hours]]
     |OralROA_Aftereffects=[[Oral min afterglow time::x]] - [[Oral max afterglow time::y]] [[Oral afterglow time units::hours]]
    |SublingualROA=false
    |SublingualROA_Collapsed=true
    |SublingualROA_Caption=
    |SublingualROA_Bioavailability=[[Sublingual min bioavailability::x]]% - [[Sublingual max bioavailability::y]]%
    |SublingualROA_Microdose=
    |SublingualROA_Threshold=[[Sublingual threshold dose::x]] - [[Sublingual dose units::mg]]
    |SublingualROA_Light=[[Sublingual min light dose::x]] - [[Sublingual max light dose::y]] mg
    |SublingualROA_Common=[[Sublingual min common dose::x]] - [[Sublingual max common dose::y]] mg
    |SublingualROA_Strong=[[Sublingual min strong dose::x]] - [[Sublingual max strong dose::y]] mg
    |SublingualROA_Heavy=[[Sublingual heavy dose::x]] mg +
    |SublingualROA_TimelineFile=
    |SublingualROA_TimelineWidth=
    |SublingualROA_Duration=[[Sublingual min total time::a]] - [[Sublingual max total time::b]] [[Sublingual total time units::hours]]
    |SublingualROA_Onset=[[Sublingual min onset time::a]] - [[Sublingual max onset time::b]] [[Sublingual onset time units::minutes]]
    |SublingualROA_Comeup=[[Sublingual min comeup time::a]] - [[Sublingual max comeup time::b]] [[Sublingual comeup time units::minutes]]
    |SublingualROA_Peak=[[Sublingual min peak time::a]] - [[Sublingual max peak time::b]] [[Sublingual peak time units::hours]]
    |SublingualROA_Offset=[[Sublingual min offset time::a]] - [[Sublingual max offset time::b]] [[Sublingual offset time units::hours]]
    |SublingualROA_Aftereffects=[[Sublingual min afterglow time::a]] - [[Sublingual max afterglow time::b]] [[Sublingual afterglow time units::hours]]
    |BuccalROA=false
    |BuccalROA_Collapsed=True
    |BuccalROA_Caption=
    |BuccalROA_Bioavailability=[[Buccal min bioavailability::x]]% - [[Buccal max bioavailability::y]]%<ref>APA formatted citation</ref>
    |BuccalROA_Microdose=
    |BuccalROA_Threshold=[[Buccal threshold dose::x]] -  [[Buccal dose units::mg]]
    |BuccalROA_Light=[[Buccal min light dose::x]] - [[Buccal max light dose::y]] mg
    |BuccalROA_Common=[[Buccal min common dose::x]] - [[Buccal max common dose::y]] mg
    |BuccalROA_Strong=[[Buccal min strong dose::x]] - [[Buccal max strong dose::y]] mg
    |BuccalROA_Heavy=[[Buccal heavy dose::x]] mg +
    |BuccalROA_TimelineFile=
    |BuccalROA_TimelineWidth=
    |BuccalROA_Duration=[[Buccal min total time::x]] - [[Buccal max total time::y]] [[Buccal total time units::hours]]
    |BuccalROA_Onset=[[Buccal min onset time::x]] - [[Buccal max onset time::y]] [[Buccal onset time units::minutes]]
    |BuccalROA_Comeup=[[Buccal min comeup time::x]] - [[Buccal max comeup time::y]] [[Buccal comeup time units::minutes]]
    |BuccalROA_Peak=[[Buccal min peak time::x]] - [[Buccal max peak time::y]] [[Buccal peak time units::hours]]
    |BuccalROA_Offset=[[Buccal min offset time::x]] - [[Buccal max offset time::y]] [[Buccal offset time units::hours]]
    |BuccalROA_Aftereffects=[[Buccal min afterglow time::x]] - [[Buccal max afterglow time::y]] [[Buccal afterglow time units::hours]]


     |InsufflatedROA=true
     |InsufflatedROA=true
     |InsufflatedROA_Collapsed=True
     |InsufflatedROA_Collapsed=false
     |InsufflatedROA_Caption=
     |InsufflatedROA_Caption=
     |InsufflatedROA_Bioavailability=
     |InsufflatedROA_Bioavailability=
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     |InsufflatedROA_Offset=[[Insufflated min offset time::x]] - [[Insufflated max offset time::y]] [[Insufflated offset time units::hours]]
     |InsufflatedROA_Offset=[[Insufflated min offset time::x]] - [[Insufflated max offset time::y]] [[Insufflated offset time units::hours]]
     |InsufflatedROA_Aftereffects=[[Insufflated min afterglow time::x]] - [[Insufflated max afterglow time::y]] [[Insufflated afterglow time units::hours]]
     |InsufflatedROA_Aftereffects=[[Insufflated min afterglow time::x]] - [[Insufflated max afterglow time::y]] [[Insufflated afterglow time units::hours]]
    |RectalROA=false
    |RectalROA_Collapsed=True
    |RectalROA_Caption=
    |RectalROA_Bioavailability=[[Rectal min bioavailability::x]]% - [[Rectal max bioavailability::y]]
    |RectalROA_Microdose=
    |RectalROA_Threshold=[[Rectal threshold dose::x]] -  [[Rectal dose units::mg]]
    |RectalROA_Light=[[Rectal min light dose::x]] - [[Rectal max light dose::y]] mg
    |RectalROA_Common=[[Rectal min common dose::x]] - [[Rectal max common dose::y]] mg
    |RectalROA_Strong=[[Rectal min strong dose::x]] - [[Rectal max strong dose::y]] mg
    |RectalROA_Heavy=[[Rectal heavy dose::x]] mg +
    |RectalROA_TimelineFile=
    |RectalROA_TimelineWidth=
    |RectalROA_Duration=[[Rectal min total time::x]] - [[Rectal max total time::y]] [[Rectal total time units::hours]]
    |RectalROA_Onset=[[Rectal min onset time::x]] - [[Rectal max onset time::y]] [[Rectal onset time units::minutes]]
    |RectalROA_Comeup=[[Rectal min comeup time::x]] - [[Rectal max comeup time::y]] [[Rectal comeup time units::minutes]]
    |RectalROA_Peak=[[Rectal min peak time::x]] - [[Rectal max peak time::y]] [[Rectal peak time units::hours]]
    |RectalROA_Offset=[[Rectal min offset time::x]] - [[Rectal max offset time::y]] [[Rectal offset time units::hours]]
    |RectalROA_Aftereffects=[[Rectal min afterglow time::x]] - [[Rectal max afterglow time::y]] [[Rectal afterglow time units::hours]]
    |TransdermalROA=false
    |TransdermalROA_Collapsed=True
    |TransdermalROA_Caption=
    |TransdermalROA_Bioavailability=[[Transdermal min bioavailability::x]]% - [[Transdermal max bioavailability::y]]%<ref>APA formatted citation</ref>
    |TransdermalROA_Microdose=
    |TransdermalROA_Threshold=[[Transdermal threshold dose::x]] -  [[Transdermal dose units::mg]]
    |TransdermalROA_Light=[[Transdermal min light dose::x]] - [[Transdermal max light dose::y]] mg
    |TransdermalROA_Common=[[Transdermal min common dose::x]] - [[Transdermal max common dose::y]] mg
    |TransdermalROA_Strong=[[Transdermal min strong dose::x]] - [[Transdermal max strong dose::y]] mg
    |TransdermalROA_Heavy=[[Transdermal heavy dose::x]] mg +
    |TransdermalROA_TimelineFile=
    |TransdermalROA_TimelineWidth=
    |TransdermalROA_Duration=[[Transdermal min total time::x]] - [[Transdermal max total time::y]] [[Transdermal total time units::hours]]
    |TransdermalROA_Onset=[[Transdermal min onset time::x]] - [[Transdermal max onset time::y]] [[Transdermal onset time units::minutes]]
    |TransdermalROA_Comeup=[[Transdermal min comeup time::x]] - [[Transdermal max comeup time::y]] [[Transdermal comeup time units::minutes]]
    |TransdermalROA_Peak=[[Transdermal min peak time::x]] - [[Transdermal max peak time::y]] [[Transdermal peak time units::hours]]
    |TransdermalROA_Offset=[[Transdermal min offset time::x]] - [[Transdermal max offset time::y]] [[Transdermal offset time units::hours]]
    |TransdermalROA_Aftereffects=[[Transdermal min afterglow time::x]] - [[Transdermal max afterglow time::y]] [[Transdermal afterglow time units::hours]]
    |SubcutaneousROA=false
    |SubcutaneousROA_Collapsed=True
    |SubcutaneousROA_Caption=
    |SubcutaneousROA_Bioavailability=[[Subcutaneous min bioavailability::x]]% - [[Subcutaneous max bioavailability::y]]%<ref>APA formatted citation</ref>
    |SubcutaneousROA_Microdose=
    |SubcutaneousROA_Threshold=[[Subcutaneous threshold dose::x]] -  [[Subcutaneous dose units::mg]]
    |SubcutaneousROA_Light=[[Subcutaneous min light dose::x]] - [[Subcutaneous max light dose::y]] mg
    |SubcutaneousROA_Common=[[Subcutaneous min common dose::x]] - [[Subcutaneous max common dose::y]] mg
    |SubcutaneousROA_Strong=[[Subcutaneous min strong dose::x]] - [[Subcutaneous max strong dose::y]] mg
    |SubcutaneousROA_Heavy=[[Subcutaneous heavy dose::x]] mg +
    |SubcutaneousROA_TimelineFile=
    |SubcutaneousROA_TimelineWidth=
    |SubcutaneousROA_Duration=[[Subcutaneous min total time::x]] - [[Subcutaneous max total time::y]] [[Subcutaneous total time units::hours]]
    |SubcutaneousROA_Onset=[[Subcutaneous min onset time::x]] - [[Subcutaneous max onset time::y]] [[Subcutaneous onset time units::minutes]]
    |SubcutaneousROA_Comeup=[[Subcutaneous min comeup time::x]] - [[Subcutaneous max comeup time::y]] [[Subcutaneous comeup time units::minutes]]
    |SubcutaneousROA_Peak=[[Subcutaneous min peak time::x]] - [[Subcutaneous max peak time::y]] [[Subcutaneous peak time units::hours]]
    |SubcutaneousROA_Offset=[[Subcutaneous min offset time::x]] - [[Subcutaneous max offset time::y]] [[Subcutaneous offset time units::hours]]
    |SubcutaneousROA_Aftereffects=[[Subcutaneous min afterglow time::x]] - [[Subcutaneous max afterglow time::y]] [[Subcutaneous afterglow time units::hours]]
    |IntramuscularROA=true
    |IntramuscularROA_Collapsed=true
    |IntramuscularROA_Caption=
    |IntramuscularROA_Bioavailability=[[Intramuscular min bioavailability::x]]% - [[Intramuscular max bioavailability::y]]%<ref>APA formatted citation</ref>
    |IntramuscularROA_Microdose=
    |IntramuscularROA_Threshold=[[Intramuscular threshold dose::x]] -  [[Intramuscular dose units::mg]]
    |IntramuscularROA_Light=[[Intramuscular min light dose::x]] - [[Intramuscular max light dose::y]] mg
    |IntramuscularROA_Common=[[Intramuscular min common dose::x]] - [[Intramuscular max common dose::y]] mg
    |IntramuscularROA_Strong=[[Intramuscular min strong dose::x]] - [[Intramuscular max strong dose::y]] mg
    |IntramuscularROA_Heavy=[[Intramuscular heavy dose::x]] mg +
    |IntramuscularROA_TimelineFile=
    |IntramuscularROA_TimelineWidth=
    |IntramuscularROA_Duration=[[Intramuscular min total time::x]] - [[Intramuscular max total time::y]] [[Intramuscular total time units::hours]]
    |IntramuscularROA_Onset=[[Intramuscular min onset time::x]] - [[Intramuscular max onset time::y]] [[Intramuscular onset time units::minutes]]
    |IntramuscularROA_Comeup=[[Intramuscular min comeup time::x]] - [[Intramuscular max comeup time::y]] [[Intramuscular comeup time units::minutes]]
    |IntramuscularROA_Peak=[[Intramuscular min peak time::x]] - [[Intramuscular max peak time::y]] [[Intramuscular peak time units::hours]]
    |IntramuscularROA_Offset=[[Intramuscular min offset time::x]] - [[Intramuscular max offset time::y]] [[Intramuscular offset time units::hours]]
    |IntramuscularROA_Aftereffects=[[Intramuscular min afterglow time::x]] - [[Intramuscular max afterglow time::y]] [[Intramuscular afterglow time units::hours]]
    |IntravenousROA=true
    |IntravenousROA_Collapsed=true
    |IntravenousROA_Caption=
    |IntravenousROA_Bioavailability=[[Intravenous min bioavailability::x]]% - [[Intravenous max bioavailability::y]]%<ref>APA formatted citation</ref>
    |IntravenousROA_Microdose=
    |IntravenousROA_Threshold=[[Intravenous threshold dose::x]] -  [[Intravenous dose units::mg]]
    |IntravenousROA_Light=[[Intravenous min light dose::x]] - [[Intravenous max light dose::y]] mg
    |IntravenousROA_Common=[[Intravenous min common dose::x]] - [[Intravenous max common dose::y]] mg
    |IntravenousROA_Strong=[[Intravenous min strong dose::x]] - [[Intravenous max strong dose::y]] mg
    |IntravenousROA_Heavy=[[Intravenous heavy dose::x]] mg +
    |IntravenousROA_TimelineFile=
    |IntravenousROA_TimelineWidth=
    |IntravenousROA_Duration=[[Intravenous min total time::x]] - [[Intravenous max total time::y]] [[Intravenous total time units::hours]]
    |IntravenousROA_Onset=[[Intravenous min onset time::x]] - [[Intravenous max onset time::y]] [[Intravenous onset time units::minutes]]
    |IntravenousROA_Comeup=[[Intravenous min comeup time::x]] - [[Intravenous max comeup time::y]] [[Intravenous comeup time units::minutes]]
    |IntravenousROA_Peak=[[Intravenous min peak time::x]] - [[Intravenous max peak time::y]] [[Intravenous peak time units::hours]]
    |IntravenousROA_Offset=[[Intravenous min offset time::x]] - [[Intravenous max offset time::y]] [[Intravenous offset time units::hours]]
    |IntravenousROA_Aftereffects=[[Intravenous min afterglow time::x]] - [[Intravenous max afterglow time::y]] [[Intravenous afterglow time units::hours]]


}}
}}
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Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication
Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication


==Chemistry==
{{chemistry}}
==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{pharmacology}}
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==Subjective effects==
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
{{effects/base
{{effects/base
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|{{effects/physical|
|{{effects/physical|


*'''[[Nasal decongestion]]'''
*'''[[Effect::Pupil dilation]]''' - Most common when used in eye drops  
*'''[[Effect::Pupil dilation]]''' - Most common when used in eye drops  
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
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* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://isomerdesign.com/PiHKAL/explore.php?id=6157&name=Phenylephrine Phenylephrine (Isomer Design)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (Drugs.com)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (Drugs.com)]
* [https://pubchem.ncbi.nlm.nih.gov/compound/6041 Phenylephrine (Pubchem)]  
* [https://pubchem.ncbi.nlm.nih.gov/compound/6041 Phenylephrine (Pubchem)]  

Revision as of 18:22, 13 March 2023

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It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.

Summary sheet: Phenylephrine
Phenylephrine
{{{SkeletalImageWidth}}}
{{{SkeletalImageWidth}}}
Chemical Nomenclature
Common names Phenylephrine
Substitutive name Neo-synephrine, m-Synephrine, β-HO-N-Me-3-HPEA
Systematic name 3-[1-Hydroxy-2-(methylamino)ethyl]phenol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Bioavailability 38% - 38%
Threshold 3 - mg
Light 5 - 9 mg
Common 10 - y mg
Strong x - 59 mg
Heavy 60 mg +
Duration
Total 4 - 4 hours
Onset 20 - 20 minutes
Come up x - y minutes
Peak x - y hours
Offset x - y hours
After effects x - y hours



⇣ Insufflated
Dosage
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total x - y hours
Onset x - y minutes
Come up x - y minutes
Peak x - y hours
Offset x - y hours
After effects x - y hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Phenylephrine is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.

Phenylephrine is used as an alternative to pseudoephedrine as a decongestant, whose availability has been restricted due to a potential for use in the illicit synthesis of Methamphetamine . Its efficacy as an oral decongestant has been questioned, with several independent studies finding that it provided no more relief to sinus congestion than a placebo.


History and culture

This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication

Pharmacology

This pharmacology section is incomplete.

You can help by adding to it.

Phenylephrine is a sympathomimetic drug, which means that it mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha-1 receptors which causes venous and arterial vasoconstriction.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Cognitive effects

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

The median lethal dose of phenylephrine taken orally at which 50% of participants die (LD50) for rats is 350mg/kg

Tolerance and addiction potential

Non-addictive with a low potential of abuse

Dangerous interactions

This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

The increase in blood pressure effect of phenylephrine may be increased by drugs such as monoamine oxidase inhibitors, tricyclic antidepressants, and hydrocortisone. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.

Drugs that may decrease the effects of phenylephrine may include calcium channel blockers, ACE inhibitors and benzodiazepines. Patients taking these medications may need a higher dose of phenylephrine to achieve a comparable increase in blood pressure.

  • Australia: Phenylephrine is a Schedule 2 (Pharmacy medicine) drug.
  • United Kingdom: Phenylephrine is an OTC drug.
  • United States: Phenylephrine is an OTC drug.

See also

References

Retrieved from "https://psy.st/index.php?title=Talk:Phenylephrine&oldid=199411"