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Cytochrome P450 inhibitors: Difference between revisions
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[[Cytochrome P450 inhibitor|Cytochrome P450 inhibitors]] inhibit the ability of the human body to break down certain substances, potentially increasing the amount of time a substance is active in the body. | |||
In some cases, this inhibition of how substances are broken down in the body can lead to dangerous adverse effects. Under some conditions, this can be fatal. | In some cases, this inhibition of how substances are broken down in the body can lead to dangerous adverse effects. Under some conditions, this can be fatal. | ||
* Black Cohosh (''Cimicifuga racemosa''): CYP3A4<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142198/</ref> | * Black Cohosh (''Cimicifuga racemosa''): CYP3A4<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142198/</ref> | ||
Revision as of 11:52, 21 November 2018
Make sure to check the MAOI#Interactions
Some CYP450 inhibitors are also MAOIs.
Cytochrome P450 inhibitors inhibit the ability of the human body to break down certain substances, potentially increasing the amount of time a substance is active in the body.
In some cases, this inhibition of how substances are broken down in the body can lead to dangerous adverse effects. Under some conditions, this can be fatal.
- Black Cohosh (Cimicifuga racemosa): CYP3A4[1]
- Talk:Cannabidiol: CYP3A4 and CYP3A5.[2]
- Fluoxetine[3]
- Grapefruit: Bergamottin, a natural furanocoumarin in both grapefruit flesh and peel that inhibits the CYP3A4
- Goldenseal: CYP2D6, CYP3A4 and CYP3A5[4]
- Watercress: CYP2E1[5]
- St. John’s Wort: CYP3A4 and CYP1A2[6]
- Star fruit, aka carambola (from Averrhoa carambola): CYP2A6[7]
- MAOIs
- Harmaline (found in Peganum harmala): CYP2D6[8]
- Harmine (found in Peganum harmala): CYP2D6[8]
- Harmol (found in Peganum harmala): CYP2D6[8]
- Talk:Moclobemide: CYP2C19, CYP2D6, and CYP1A2[9]
- Piperine: CYP3A4[10]
- Quercetin (found in Nutmeg (Myristica fragrans) and Passionflower (Passiflora incarnata)): CYP2D6 and a moderate effect against CYP2C19 and CYP3A4[11]
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142198/
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/21356216
- ↑ https://drug-interactions.medicine.iu.edu/clinical-table.aspx
- ↑ Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Khan IA, Shah A (2005). "In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes". Clin. Pharmacol. Ther. 77: 415–26. doi:10.1016/j.clpt.2005.01.009. PMC 1894911
. PMID 15900287.
- ↑ Leclercq, Isabelle; Desager, Jean-Pierre; Horsmans, Yves (1998). "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress". Clinical Pharmacology & Therapeutics. 64 (2): 144–9. doi:10.1016/S0009-9236(98)90147-3. PMID 9728894.
- ↑ Wenk M, Todesco L, Krähenbühl S (2004). "Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females" (PDF). Br J Clin Pharmacol. 57 (4): 495–499. doi:10.1111/j.1365-2125.2003.02049.x. PMC 1884478 . PMID 15025748.
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/18261370
- ↑ 8.0 8.1 8.2 https://www.ncbi.nlm.nih.gov/pubmed/21433154
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/7781267
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/12130727
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822518/