Substituted phenidates: Difference between revisions
>BronzeManul m Grammatics |
>BronzeManul Replaced skeletal structure images with standardised svg images. |
||
| Line 18: | Line 18: | ||
! scope="col" | '''Structure''' | ! scope="col" | '''Structure''' | ||
|- | |- | ||
| [[Methylphenidate]] || H || H || CH<sub>3</sub> || [[File: | | [[Methylphenidate]] || H || H || CH<sub>3</sub> || [[File:Methylphenidate.svg|170px]] | ||
|- | |- | ||
| [[Ethylphenidate]] || H || H || CH<sub>2</sub>CH<sub>3</sub> || [[File: | | [[Ethylphenidate]] || H || H || CH<sub>2</sub>CH<sub>3</sub> || [[File:Ethylphenidate.svg|170px]] | ||
|- | |- | ||
| [[Isopropylphenidate]] || H || H || CH(CH<sub>3</sub>)<sub>2</sub> || [[File:Isopropylphenidate. | | [[Isopropylphenidate]] || H || H || CH(CH<sub>3</sub>)<sub>2</sub> || [[File:Isopropylphenidate.svg|170px]] | ||
|- | |- | ||
| Propylphenidate || H || H || CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> || [[File:Propylphenidate. | | Propylphenidate || H || H || CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> || [[File:Propylphenidate.svg|170px]] | ||
|- | |- | ||
| 4-Methylmethylphenidate || H || CH<sub>3</sub> || CH<sub>3</sub> || [[File: | | 4-Methylmethylphenidate || H || CH<sub>3</sub> || CH<sub>3</sub> || [[File:4-Methylmethylphenidate.svg|171px]] | ||
|- | |- | ||
| [[3,4-CTMP]] || Cl || Cl || CH<sub>3</sub> || [[File: | | [[3,4-CTMP]] || Cl || Cl || CH<sub>3</sub> || [[File:3,4-CTMP.svg|171px]] | ||
|- | |- | ||
| [[4F-MPH]] || H || F || CH<sub>3</sub> || [[File: | | [[4F-MPH]] || H || F || CH<sub>3</sub> || [[File:4F-MPH.svg|171px]] | ||
|- | |- | ||
| [[4F-EPH]] || H || F || CH<sub>2</sub>CH<sub>3</sub> || [[File:4F-EPH. | | [[4F-EPH]] || H || F || CH<sub>2</sub>CH<sub>3</sub> || [[File:4F-EPH.svg|171px]] | ||
|- | |- | ||
| [[Methylnaphthidate]] (''HDMP-28'') || CH=CH- || CH=CH- || CH<sub>3</sub> || [[File: | | [[Methylnaphthidate]] (''HDMP-28'') || CH=CH- || CH=CH- || CH<sub>3</sub> || [[File:Methylnaphthidate.svg|170px]] | ||
|- | |- | ||
| Ethylnaphthidate (''HDEP-28'') || CH=CH- || CH=CH- || CH<sub>2</sub>CH<sub>3</sub> || [[File:Ethylnaphthidate. | | Ethylnaphthidate (''HDEP-28'') || CH=CH- || CH=CH- || CH<sub>2</sub>CH<sub>3</sub> || [[File:Ethylnaphthidate.svg|170px]] | ||
|- | |- | ||
|} | |} | ||
Revision as of 05:21, 30 August 2017
Substituted phenidates (also known as phenidates) are a class of chemicals that include compounds that predominantly produce traditional stimulant effects when administered. They may be defined as esters of ritalinic acid and its analogs.
Chemistry
Substituted phenidates are a chemical class based upon the molecule methylphenidate. The molecular structure of methylphenidate is comprised of a phenethylamine core with a carbon chain substitution at the Rα position that links to the RN position, forming a piperidine ring. It also includes a substitution at the Rβ position of methyl acetate.
Pharmacology
 |
This pharmacology section is incomplete. You can help by adding to it. |
Substituted phenidates primarily act as reuptake inhibitors of the monoamine neurotransmitters dopamine and norepinephrine, with the occasional addition of serotonin.[citation needed]
List of substituted phenidates
| Compound | R3 | R4 | RO | Structure |
|---|---|---|---|---|
| Methylphenidate | H | H | CH3 | 
|
| Ethylphenidate | H | H | CH2CH3 | 
|
| Isopropylphenidate | H | H | CH(CH3)2 | 
|
| Propylphenidate | H | H | CH2CH2CH3 | 
|
| 4-Methylmethylphenidate | H | CH3 | CH3 | 
|
| 3,4-CTMP | Cl | Cl | CH3 | 
|
| 4F-MPH | H | F | CH3 | 
|
| 4F-EPH | H | F | CH2CH3 | 
|
| Methylnaphthidate (HDMP-28) | CH=CH- | CH=CH- | CH3 | 
|
| Ethylnaphthidate (HDEP-28) | CH=CH- | CH=CH- | CH2CH3 | 
|