Deschloroketamine

Summary sheet: Deschloroketamine

Deschloroketamine
Chemical Nomenclature
Common names	Deschloroketamine, DCK, DXE, O-PCM
Substitutive name	Deschloroketamine
Systematic name	2-Phenyl-2-(methylamino)cyclohexanone
Class Membership
Psychoactive class	Dissociative
Chemical class	Arylcyclohexylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Smoked Dosage Threshold 5 mg Light 5 - 10 mg Common 10 - 20 mg Strong 20 - 40 mg Heavy 40 mg + Duration Total 30 - 90 minutes ⇣ Oral Dosage Threshold 10 mg Light 10 - 20 mg Common 20 - 30 mg Strong 30 - 50 mg Heavy 50 mg + Duration Total 4 - 6 hours Onset 10 - 30 minutes Come up 30 - 60 minutes Peak 1.5 - 2.5 hours Offset 1 - 2 hours After effects 3 - 24 hours ⇣ Insufflated Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 25 mg Strong 25 - 40 mg Heavy 40 mg + Duration Total 3 - 6 hours Onset 5 - 15 minutes Come up 30 - 60 minutes Peak 1.5 - 2.5 hours Offset 1 - 2 hours After effects 3 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Stimulants
Depressants

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a chemical of the arylcyclohexylamine class which acts as a hallucinogenic dissociative anesthetic.[1][2]

This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. DXE has recently become freely available through online research chemical vendors[1] where it is being sold as a designer drug.[3][4][5] It also acts as an antibiotic.[6]

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

Main article: NMDA receptor antagonist

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, DXE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the famous “hole.”

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Muscle relaxation (add to all dissos)
• Tactile disconnection
• Spontaneous tactile sensations
• Tactile suppression
• Physical autonomy
• Motor control loss
• Physical euphoria
• Perception of decreased weight
• Dizziness
• Nausea
• Visual sliding

Cognitive effects

• Depersonalization
• Derealization
• Consciousness disconnection
• Memory suppression (ego death)
• Thought deceleration
• Immersion enhancement
• Information processing suppression
• Time distortion
• Euphoria
• Introspection
• Déjà vu
• Conceptual thinking
• Unity and interconnectedness
• Compulsive redosing
• Anxiety
• Disinhibition
• Amnesia
• Creativity enhancement
• Language suppression also add to ket

Visual effects

Suppression

• Visual disconnection - This eventually results in DXE's equivalent of the famous "k-hole" or, more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision
• Pattern recognition suppression
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Hallucinatory states

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Suppression
• Distortions
• Hallucinations

Toxicity and harm potential

The toxicity and long-term health effects of recreational DXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DXE has very little history of human usage. Anecdotal evidence from people who have tried DXE within the community confirm that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself or using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of DXE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings may occur if a person suddenly stops their usage.

Tolerance to many of the effects of DXE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Note that DXE presents cross-tolerance with [[Cross-tolerance::all dissociatives]], meaning that after the consumption of DXE all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, DXE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because DXE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
• Urinary urgency - This can be described as a sudden, compelling need to urinate.
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
• Hematuria - Hematuria is visible blood in the urine.
• Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using DXE on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
• Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• Latvia - Deschloroketamine is illegal in Latvia,[7]
• UK - Deschloroketamine is illegal in the UK.

See also

• Dissociative
• MXE
• Ketamine

External links

• Deschloroketamine (Wikipedia)
• Deschloroketamine (Bluelight)