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==initial draft. This will contain a myriad of information and will be formatted later :) --[[User:Corticosteroid|Corticosteroid]] ([[User talk:Corticosteroid|talk]]) 22:58, 20 October 2017 (CEST)==
{{SummarySheet}}
[[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]
{{SubstanceBox/Olanzapine}}
[[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]
'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}
'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}
==Chemistry==
==Chemistry==
Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R<sub>4</sub>.
Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R<sub>4</sub>.
Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. [[User:Syrex1013|Syrex1013]] ([[User talk:Syrex1013|talk]]) 00:26, 27 June 2025 (UTC)
==Pharmacology==
==Pharmacology==
Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other [[antipsychotics]]. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>
Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other [[antipsychotics]]. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>
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|{{effects/cognitive|
|{{effects/cognitive|
*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and serotonergic action rather than GABA-related activity.
*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
*'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.
*'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.
*'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.
*'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.
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===Experience reports===
There are currently {{#ask:[[Category:Olanzapine]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Olanzapine, first branded as Zyprexa, is a widely-used antipsychotic substance of the thienobenzodiazepine chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given by mouth and can also be injected into a muscle. Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. [citation needed]
Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R4.
Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. Syrex1013 (talk) 00:26, 27 June 2025 (UTC)
Pharmacology
Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other antipsychotics. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.[2]
Subjective effects
Physical effects
Hunger - This often happens over a course of treatment and not with one use.
Sedation - This effect is more often uncomfortably tiring than relaxing.
Anxiety suppression - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
↑Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.
