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Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.
Combinations with the following substances can cause dangerously high [[serotonin]] levels. [[Serotonin syndrome]] requires immediate medical attention and can be fatal if left untreated.
*'''[[DangerousInteraction::MAOIs]]''' such as '''[[syrian rue]]''', '''[[banisteriopsis caapi]]''', '''[[2C-T-2]]''', '''[[2C-T-7]]''', '''[[αMT]]''', and some [[antidepressant]]s<ref>Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https//doi.org/10.1093/bja/aei210</ref>
*'''[[DangerousInteraction::MAOIs]]''' - {{#switch:{{{self}}}
*'''[[DangerousInteraction::Serotonin releasers]]''' such as '''[[MDMA]]''', '''[[4-FA]]''', '''[[MDAI]]''' and '''[[αMT]]'''
|Syrian_rue=Such as [[banisteriopsis caapi]], phenelzine, selegiline, and moclobemide.
*'''[[DangerousInteraction::Selective serotonin re-uptake inhibitors]] (SSRIs)'''
|Banisteriopsis_caapi=Such as [[syrian rue]], phenelzine, selegiline, and moclobemide.
*'''[[DangerousInteraction::Serotonin-norepinephrine reuptake inhibitors]] (SNRIs)'''
|Such as [[banisteriopsis caapi]], [[syrian rue]], phenelzine, selegiline, and moclobemide.}}<ref>{{cite journal|last1=Gillman|first1=P. K.|year=2005|title=Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity|journal=British Journal of Anaesthesia|volume=95|issue=4|url=https://bjanaesthesia.org/article/S0007-0912(17)34956-5/fulltext|pages=434-441|doi=10.1093/bja/aei210|pmid=16051647|doi-access=free|issn=0007-0912|eissn=1471-6771|oclc=01537271}}</ref>
*'''[[DangerousInteraction::5-HTP]]'''
*'''[[DangerousInteraction::Serotonin releasers]]''' - {{#switch:{{{self}}}
|MDMA=Such as [[4-FA]], [[methamphetamine]], [[methylone]] and [[αMT]].
|4-FA=Such as [[MDMA]], [[methamphetamine]], [[methylone]] and [[αMT]].
|Methamphetamine=Such as [[MDMA]], [[4-FA]], [[methylone]] and [[αMT]].
|Methylone=Such as [[MDMA]], [[4-FA]], [[methamphetamine]] and [[αMT]].
|AMT=Such as [[MDMA]], [[4-FA]], [[methamphetamine]] and [[methylone]].
|Such as [[MDMA]], [[4-FA]], [[methamphetamine]], [[methylone]] and [[αMT]].}}
*'''[[DangerousInteraction::SSRIs]]''' - Such as citalopram and sertraline
*'''[[Wikipedia:SNRIs|[[DangerousInteraction::SNRIs]]]]''' - Such as {{#ifeq:{{{self}}}|Tramadol|venlafaxine|[[tramadol]] and venlafaxine}}
{{#ifeq:{{{self}}}|5-HTP||*'''[[DangerousInteraction::5-HTP]]'''}}

Latest revision as of 21:00, 15 September 2022

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

  1. ↑ Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210 Freely accessible. eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
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