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{{SubstanceBox/Estradiol}}
{{SubstanceBox/Estradiol}}
'''Estradiol''' (also known as '''estrogen''', '''oestradiol''', '''E''' or '''E2''') is an [[estrogen]] steroid hormone and the major female sex hormone.
'''Estradiol''' (also known as '''oestradiol''', '''E''' or '''E2''') is an [[estrogen]] steroid hormone and the major female sex hormone.
==History and culture==
==History and culture==
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==Chemistry==
==Chemistry==
===Esters===
===Esters===
As a medication '''estradiol''' is more commonly administered in the form of [[prodrug]] esters to improve duration of action.
As a medication '''estradiol''' is commonly(especially when injected) administered in the form of [[prodrug]] esters to improve duration of action.
{| class="wikitable"
{| class="wikitable"
|-
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*'''[[Effect::Decreased libido]]'''
*'''[[Effect::Decreased libido]]'''
*'''[[Effect::Orgasm depression]]''' commonly in transgender women and cis men.
*'''[[Effect::Orgasm depression]]'''
*'''[[Effect::Body odor alteration]]''' commonly in transgender women and cis men.
*'''[[Effect::Body odor alteration]]'''
*'''[[Effect::Body fat redistribution]]'''
*'''[[Effect::Breast growth]]'''
*'''[[Effect::Reduction of body hair]]'''
*'''[[Effect::Softening of the skin]]'''
}}
}}
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*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
*'''[[Effect::Cognitive euphoria]]''' Estradiol may directly produce feelings of euphoria in women aswell as added euphoria in transwomen due to gender affirming physical effects.
*'''[[Effect::Cognitive euphoria]]''' Estradiol may directly produce feelings of euphoria in feminine people aswell as added euphoria due to gender affirming physical effects.
*'''[[Effect::Cognitive dysphoria]]''' commonly in Men.
*'''[[Effect::Cognitive dysphoria]]''' Estradiol might produce gender-dysphoria in masculine people
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Estradiol (also known as oestradiol, E or E2) is an estrogen steroid hormone and the major female sex hormone.
It is a basic, natural estrogen. Chemically, it is a steroid, a derivative of estrone.
Responsible for the development of the female reproductive organs, proliferation of the endometrium, regulates the sexual cycle and affects sexual behavior. During the follicular phase, it is produced mainly in the ovaries by growing Graaf follicles. In the corpus luteum phase, it is secreted in very small amounts by the corpus luteum. It is also produced in the adrenal cortex and during pregnancy in the placenta.
Chemistry
Esters
As a medication estradiol is commonly(especially when injected) administered in the form of prodrug esters to improve duration of action.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Estradiol has feminzing develomental effects on the human body in regards of fat distribution, muscles mass and sexual characteristics.
Cognitive euphoria Estradiol may directly produce feelings of euphoria in feminine people aswell as added euphoria due to gender affirming physical effects.
Cognitive dysphoria Estradiol might produce gender-dysphoria in masculine people
