Talk:Acetylcholinesterase inhibitor: Difference between revisions
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==Acetylcholinesterase inhibitors== | ==Acetylcholinesterase inhibitors== | ||
* ''[[Banisteriopsis caapi]]'' | |||
** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref> | |||
** Harmine<ref name="Pubmed-19784581" /> | |||
* [[Caffeine]] | * [[Caffeine]] | ||
* [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'') | * [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'') | ||
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==Dangerous interactions== | ==Dangerous interactions== | ||
{{GenericPanel/warning | {{GenericPanel/warning | ||
| title=Check ( | | title=Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also [[MAOI]]s and [[cytochrome P450 inhibitors]]. | ||
| content=Substances that | | content=Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times. | ||
When the MAO enzymes and CYP450 system | When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose. | ||
}} | }} | ||
AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis]. | AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis]. | ||
==See also== | |||
* [[Cholinergic]] | |||
==References== | ==References== | ||
Latest revision as of 22:39, 12 July 2022
An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
Acetylcholinesterase inhibitors
- Banisteriopsis caapi
- Caffeine
- Harmala alkaloids (found in Peganum harmala)
- Piperine (found in Black pepper (Piper nigrum), and Long pepper (Piper longum))
Dangerous interactions
Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also MAOIs and cytochrome P450 inhibitors.
Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times. When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
AChEIs combined with cholinergic substances can result in a cholinergic crisis.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 https://www.ncbi.nlm.nih.gov/pubmed/19784581
- ↑ Studies in Natural Products Chemistry, Volume 43, page 43
- ↑ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366