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'''Restless legs''' (also known as '''restless legs syndrome''' or '''RLS''') is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. It most commonly affects the legs, but can affect the arms, torso, head, and even phantom limbs. Moving the affected body part modulates the sensations, providing temporary relief.
'''Restless legs''' (also known as '''restless legs syndrome''' or '''RLS''') is a medically defined as an irresistible urge to move one's body to stop uncomfortable or odd sensations.<ref name="ICD-11-Restless-legs-syndrome">{{cite journal|title=Restless legs syndrome|journal=International statistical classification of diseases and related health problems (11th ed.)|year=2022|url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1254916765 | access-date=20 May 2022}}</ref> It most commonly affects the legs but can also affect the arms, torso, and head. During this state, moving the affected body part reduces the uncomfortable sensations, providing temporary relief.


RLS sensations range from pain or an aching in the muscles to "an itch you can't scratch", an unpleasant "tickle that won't stop", or even a crawling feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.
RLS sensations can range from pain, an aching in the muscles, "an itch you can't scratch", an unpleasant "tickle that won't stop", or even a crawling feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.


In the context of substance usage, certain compounds induce states of restless leg syndrome throughout the experience of them. This can be mild in its effects or extremely intense and uncomfortable. [[Opiate]] withdrawal can produce this effect as well.
Restless legs syndrome is most commonly induced during the [[withdrawal]] symptoms of many [[depressant|depressants]], such as [[opioid|opioids]] or [[benzodiazepine|benzodiazepines]], and during the [[offset]] of many [[stimulants]], such as [[methamphetamine]], [[cocaine]], and [[MDMA]]. However, it can also occur under the influence of [[deliriant|deliriants]] such as [[DPH]] and [[datura]].  RLS is theorized to be linked to a deficiency of dopamine, specifically a lower amount of activity at the D2 dopamine receptors.  D2 antagonists can cause restless leg syndrome in people, especially as the dosage increases, a prime example of a D2 antagonists that causes RLS is Quetiapine.
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===Psychoactive substances===
===Psychoactive substances===
Compounds within our [[psychoactive substance index]] which may cause this effect include:
Compounds within our [[psychoactive substance index]] which may cause this effect include:
{{#ask:[[Category:Psychoactive substance]][[Effect::Restless leg syndrome]]|format=ul|Columns=1}}
{{#ask:[[Category:Psychoactive substance]][[Effect::Restless leg syndrome]]|format=ul|Columns=2}}
===Experience reports===
===Experience reports===
Anecdotal reports which describe this effect within our [[experience index]] include:
Anecdotal reports which describe this effect within our [[experience index]] include:
{{#ask:[[Category:Experience]][[Effect::Restless leg syndrome]]|format=ul|Columns=2}}
{{#ask:[[Category:Experience]][[Effect::Restless leg syndrome]]|format=ul|Columns=1}}
===See also===
===See also===
*[[Responsible use]]
*[[Responsible use]]
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*[[Dissociatives#Subjective_effects|Dissociatives - Subjective effects]]
*[[Dissociatives#Subjective_effects|Dissociatives - Subjective effects]]
*[[Deliriants#Subjective_effects|Deliriants - Subjective effects]]
*[[Deliriants#Subjective_effects|Deliriants - Subjective effects]]
[[Category:Uncomfortable]][[Category:Effect]][[Category:Physical]]
===External links===
* [https://en.wikipedia.org/wiki/Restless_legs_syndrome Restless legs syndrome (Wikipedia)]
[[Category:Physical]][[Category:Uncomfortable]][[Category:Bodily]][[Category:Effect]]
===References===
<references/>

Latest revision as of 14:55, 19 December 2024

Restless legs (also known as restless legs syndrome or RLS) is a medically defined as an irresistible urge to move one's body to stop uncomfortable or odd sensations.[1] It most commonly affects the legs but can also affect the arms, torso, and head. During this state, moving the affected body part reduces the uncomfortable sensations, providing temporary relief.

RLS sensations can range from pain, an aching in the muscles, "an itch you can't scratch", an unpleasant "tickle that won't stop", or even a crawling feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.

Restless legs syndrome is most commonly induced during the withdrawal symptoms of many depressants, such as opioids or benzodiazepines, and during the offset of many stimulants, such as methamphetamine, cocaine, and MDMA. However, it can also occur under the influence of deliriants such as DPH and datura. RLS is theorized to be linked to a deficiency of dopamine, specifically a lower amount of activity at the D2 dopamine receptors. D2 antagonists can cause restless leg syndrome in people, especially as the dosage increases, a prime example of a D2 antagonists that causes RLS is Quetiapine.

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

Experience reports

Anecdotal reports which describe this effect within our experience index include:

See also

References

  1. ↑ "Restless legs syndrome". International statistical classification of diseases and related health problems (11th ed.). 2022. Retrieved 20 May 2022. 
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