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[[File:Phencyclidine_structure.svg | [[File:Phencyclidine_structure.svg|239px|thumb|Structure of phencyclidine]]{{Stub}} | ||
'''Phencyclidines''' refers to a class of compounds which typically produce [[dissociative]] [[anaesthesia]]. | '''Phencyclidines''' refers to a class of compounds which typically produce [[dissociative]] [[anaesthesia]]. | ||
==Chemistry== | ==Chemistry== | ||
Phencyclidines are a subclass of [[arylcyclohexylamines]] which includes [[dissociatives]] such as [[PCP]] and its derivatives. They share a core structure of a six-member saturated cyclohexane ring bound to a [[piperidine]] ring and phenyl ring at the same location R<sub>1</sub>. | |||
==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | |||
==Examples== | ==Examples== | ||
* [[3-MeO-PCMo]] | * [[3-MeO-PCMo]] | ||
* [[3-Me2'-Oxo-PCE]] | |||
* [[3-MeO-PCP]] | |||
* [[3-MeO-PCE]] | * [[3-MeO-PCE]] | ||
* [[4-MeO-PCP]] | * [[4-MeO-PCP]] | ||
* [[Ketamine]] | * [[Ketamine]] | ||
| Line 16: | Line 19: | ||
* [[Phencyclidine]] (''PCP'') | * [[Phencyclidine]] (''PCP'') | ||
==Toxicity and | ==Toxicity and harm potential== | ||
There are | {{Further|Research chemicals#Toxicity and harm potential}} | ||
===Psychosis=== | |||
Certain phencyclidines, including [[3-MeO-PCP]], [[3-MeO-PCE]], and [[PCP]], have been reported to cause [[psychosis]] and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a significant amount of reports in the medical literature and throughout online forums which describe states of psychosis, mania, [[delirium]], and/or catatonia after abusing these drugs.<ref name="three">The Big & Dandy 3-MeO-PCP Thread - Part 2 (Bluelight) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2</ref><ref name="two">The Big & Dandy 3-MeO-PCP Thread - Mad Manic Meo 3nity | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity</ref><ref name="one">The Big & Dandy 3-MeO-PCP Thread - Part 1 (Bluelight) | http://www.bluelight.org/vb/threads/454099-The-Big-amp-Dandy-3-MeO-PCP-Thread-%28Part-1%29</ref> In one initial human trial of PCP, it was reported that one-sixth of the patients who had received anaesthetic doses became psychotic.<ref name="five">http://archives.drugabuse.gov/pdf/monographs/21.pdf | Luisada, Paul V., M.D. "The Phencyclidine Psychosis: Phenomenology and Treatment." Phencyclidine (PCP) Abuse: An Appraisal. Rockville, Maryland: National Institute on Drug Abuse, 1978. pg. 241.</ref> Similar results (although less severe) were reported during trials using subanesthetic doses of PCP for pain relief.<ref name="four">Tasman, Allan, Jerald Kay, and Jeffrey A. Lieberman. Psychiatry. Chichester: John Wiley & Sons, 2003. Google Books. Wiley. Web. <https://books.google.com/books?id=l2KRBgAAQBAJ&pg=PT4957&lpg=PT4957&dq=Greifenstein+et+al.+1958%29.&source=bl&ots=s5CFdAfMzc&sig=GzsOq_N-V1qtahxyyHnKMJceEj0&hl=en&sa=X&ved=0ahUKEwji0pWTjNLKAhUBaD4KHTfqD0sQ6AEIHDAA#v=onepage&q=Greifenstein%20et%20al.%201958%29.&f=false>.</ref> | |||
In some cases, 3-MeO-PCP and PCP use has resulted in hospitalization and has occasionally taken up to a week or more to resolve.<ref name="six">Phencyclidine analog use in Sweden--intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26295489</ref><ref name="four"></ref><ref>The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 18 | 10-08-2014 09:10 | Post #448 by Sekio (Administrator) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12523821&viewfull=1#post12523821</ref><ref>The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 20 | 30-08-2014 14:08 | Post #481 by Chocodoobie | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12559322&viewfull=1#post12559322</ref><ref>The Big & Dandy 3-MeO-PCP Thread - Part 3 | Page 1 | 23-06-2015 11:53 | Post #5 by Confield | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity?p=13108675&viewfull=1#post13108675</ref><ref>https://www.erowid.org/experiences/exp.php?ID=103972 | NumbnDumb. "So Strong I'm Shocked: An Experience with 3-MeO-PCP (ID 103972)". Erowid.org. Jan 24, 2016. erowid.org/exp/103972</ref> | |||
It is strongly recommended that one use extreme caution and [[responsible drug use|harm reduction]] practices when using 3-MeO-PCP or PCP. Users should avoid taking the drugs multiple days in a row or becoming addicted as this increases the risk of severe adverse effects. The recommended dosage range should not be exceeded as high doses can trigger these effects as well. Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drugs' potencies; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCP</ref> [[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose. | |||
Due to the risk of psychosis, it is not recommended to combine these drugs with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other dissociatives like MXE. Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | |||
==See also== | ==See also== | ||
*[[ | *[[Responsible use]] | ||
*[[Dissociative]] | *[[Dissociative]] | ||
*[[Ketamine]] | *[[Ketamine]] | ||
*[[Methoxetamine]] | *[[Methoxetamine]] | ||
*[[NMDA receptor antagonist]] | *[[NMDA receptor antagonist]] | ||
==External links== | |||
*[[wikipedia:Arylcyclohexylamine|Arylcyclohexylamine (Wikipedia)]] | |||
==References== | ==References== | ||
{{reflist|2}} | |||
[[Category:Chemical class]] | |||
Latest revision as of 03:32, 5 February 2020
 |
This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Phencyclidines refers to a class of compounds which typically produce dissociative anaesthesia.
Chemistry
Phencyclidines are a subclass of arylcyclohexylamines which includes dissociatives such as PCP and its derivatives. They share a core structure of a six-member saturated cyclohexane ring bound to a piperidine ring and phenyl ring at the same location R1.
Pharmacology
 |
This pharmacology section is incomplete. You can help by adding to it. |
Examples
- 3-MeO-PCMo
- 3-Me2'-Oxo-PCE
- 3-MeO-PCP
- 3-MeO-PCE
- 4-MeO-PCP
- Ketamine
- Methoxetamine (MXE)
- Methoxyketamine
- Phencyclidine (PCP)
Toxicity and harm potential
Further information: Research chemicals § Toxicity and harm potential
Psychosis
Certain phencyclidines, including 3-MeO-PCP, 3-MeO-PCE, and PCP, have been reported to cause psychosis and mania at a significantly higher rate than other dissociatives such as ketamine, diphenidine, or MXE. There are a significant amount of reports in the medical literature and throughout online forums which describe states of psychosis, mania, delirium, and/or catatonia after abusing these drugs.[1][2][3] In one initial human trial of PCP, it was reported that one-sixth of the patients who had received anaesthetic doses became psychotic.[4] Similar results (although less severe) were reported during trials using subanesthetic doses of PCP for pain relief.[5]
In some cases, 3-MeO-PCP and PCP use has resulted in hospitalization and has occasionally taken up to a week or more to resolve.[6][5][7][8][9][10]
It is strongly recommended that one use extreme caution and harm reduction practices when using 3-MeO-PCP or PCP. Users should avoid taking the drugs multiple days in a row or becoming addicted as this increases the risk of severe adverse effects. The recommended dosage range should not be exceeded as high doses can trigger these effects as well. Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drugs' potencies; most standard milligram scales cannot accurately weigh out doses below 10-15mg.[11] Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose.
Due to the risk of psychosis, it is not recommended to combine these drugs with other substances, especially stimulants, psychedelics, or other dissociatives like MXE. Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
See also
External links
References
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 (Bluelight) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2
- ↑ The Big & Dandy 3-MeO-PCP Thread - Mad Manic Meo 3nity | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 1 (Bluelight) | http://www.bluelight.org/vb/threads/454099-The-Big-amp-Dandy-3-MeO-PCP-Thread-%28Part-1%29
- ↑ http://archives.drugabuse.gov/pdf/monographs/21.pdf | Luisada, Paul V., M.D. "The Phencyclidine Psychosis: Phenomenology and Treatment." Phencyclidine (PCP) Abuse: An Appraisal. Rockville, Maryland: National Institute on Drug Abuse, 1978. pg. 241.
- ↑ 5.0 5.1 Tasman, Allan, Jerald Kay, and Jeffrey A. Lieberman. Psychiatry. Chichester: John Wiley & Sons, 2003. Google Books. Wiley. Web. <https://books.google.com/books?id=l2KRBgAAQBAJ&pg=PT4957&lpg=PT4957&dq=Greifenstein+et+al.+1958%29.&source=bl&ots=s5CFdAfMzc&sig=GzsOq_N-V1qtahxyyHnKMJceEj0&hl=en&sa=X&ved=0ahUKEwji0pWTjNLKAhUBaD4KHTfqD0sQ6AEIHDAA#v=onepage&q=Greifenstein%20et%20al.%201958%29.&f=false>.
- ↑ Phencyclidine analog use in Sweden--intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26295489
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 18 | 10-08-2014 09:10 | Post #448 by Sekio (Administrator) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12523821&viewfull=1#post12523821
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 20 | 30-08-2014 14:08 | Post #481 by Chocodoobie | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12559322&viewfull=1#post12559322
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 3 | Page 1 | 23-06-2015 11:53 | Post #5 by Confield | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity?p=13108675&viewfull=1#post13108675
- ↑ https://www.erowid.org/experiences/exp.php?ID=103972 | NumbnDumb. "So Strong I'm Shocked: An Experience with 3-MeO-PCP (ID 103972)". Erowid.org. Jan 24, 2016. erowid.org/exp/103972
- ↑ 3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCP