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Template:DOxOD: Difference between revisions

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>Dextromethorphan
some more (heavily anecdotal) concluded infos about post-overdose experiences which I collected through research, myself and enough friends of mine
>Kenan
m Undo revision 133040 by Natzki (talk): nope
 
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The risk of a DOx overdose is present starting in or past the heavy dose range with sensitive people, or when a DOx is mixed with other substances, particularly [[stimulants]] or [[MAOI]]s. Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage and effects. The effects of a DOx overdose typically include bizarre, [[delusion|delusional]] and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], along with many other physical and psychological suppressions from the senses. The user may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects such as [[psychosis]], [[panic attack]]s and [[seizures]] which in turn further affect a dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]] may occur.{{citation needed}} Severe vasoconstriction typically develops to its peak several hours into the intoxication and may require medical assistance if blood flow is significantly cut off for extended periods of time.
The risk of a DOx overdose is present starting in or past the heavy dose range with sensitive people, or when a DOx is mixed with other substances, particularly [[stimulants]] or [[MAOI]]s. Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage and effects. The effects of a DOx overdose typically include bizarre, [[delusion|delusional]] and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], [[confusion]] and [[anxiety]]. The user may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects such as [[psychosis]], [[panic attack]]s and [[seizures]] which in turn further affect a dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]] may occur.{{citation needed}} Severe vasoconstriction typically develops to its peak several hours into the intoxication and may require medical assistance if blood flow is significantly cut off for extended periods of time.


In the event of an overdose, [[benzodiazepines]] or [[antipsychotics]] can be administered to mitigate the hyperagitative effects.{{citation needed}} A powerful vasodilator may also need to be administered to prevent a hypertensive emergency, or in more serious cases, necrosis, organ failure and death from the resulting hypoxia.{{citation needed}} As a result, emergency medical services should always be sought in the event of a DOx overdose.
In the event of an overdose, [[benzodiazepines]] or [[antipsychotics]] can be administered to mitigate the hyperagitative effects.{{citation needed}} A powerful vasodilator may also need to be administered to prevent a hypertensive emergency, or in more serious cases, necrosis, organ failure and death from the resulting hypoxia.{{citation needed}} As a result, emergency medical services should always be sought in the event of a DOx overdose.
It is also not uncommon for people who have overdosed to have a (often negative) changed perception of reality afterwards, most commonly [[anxiety]] and uncomfortable feelings of being in a fake reality. Many people describe this as "being in a movie that is played just for you". This can persist for days to months and may be accompanied by [[HPPD]]. It is speculated that this happens because DOxs have a greater array of strong affinity for multiple serotonin receptor subtypes, which contribute to many uncomfortable effects and long-lasting changes in perception and are therefore more likely to cause a severe trauma also associated with near-death-type experiences in an overdose.{{citation needed}} It is further interesting to note that these difficult experiences are sometimes, if not more frequently seen to cause a lasting change in a person who underwent this experience, similar to [[DMT]].

Latest revision as of 21:55, 15 January 2019

The risk of a DOx overdose is present starting in or past the heavy dose range with sensitive people, or when a DOx is mixed with other substances, particularly stimulants or MAOIs. Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage and effects. The effects of a DOx overdose typically include bizarre, delusional and sometimes violent behavior, amnesia, numbness, confusion and anxiety. The user may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects such as psychosis, panic attacks and seizures which in turn further affect a dangerously elevated heart rate, blood pressure and vasoconstriction may occur.[citation needed] Severe vasoconstriction typically develops to its peak several hours into the intoxication and may require medical assistance if blood flow is significantly cut off for extended periods of time.

In the event of an overdose, benzodiazepines or antipsychotics can be administered to mitigate the hyperagitative effects.[citation needed] A powerful vasodilator may also need to be administered to prevent a hypertensive emergency, or in more serious cases, necrosis, organ failure and death from the resulting hypoxia.[citation needed] As a result, emergency medical services should always be sought in the event of a DOx overdose.