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'''Perazine''' is a typical antipsychotic medication used in the treatment of various psychiatric disorders, including schizophrenia and manic episodes associated with bipolar disorder.

==History and Development==
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Perazine was first synthesized in the 1950s and gained popularity as an antipsychotic medication during the mid-20th century. It belongs to the phenothiazine class of antipsychotics, which were among the earliest developed medications for treating psychosis.

==Chemistry==
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Perazine is a derivative of phenothiazine and structurally similar to other typical antipsychotic drugs such as chlorpromazine and trifluoperazine. It exerts its therapeutic effects by blocking dopamine receptors in the brain, particularly the D2 receptors.

==Pharmacology==
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Perazine acts primarily as a dopamine antagonist, binding to dopamine receptors in various regions of the brain. By blocking the effects of dopamine, it helps alleviate symptoms of psychosis such as hallucinations, delusions, and disorganized thinking.

==Indications==
Perazine is indicated for the treatment of schizophrenia and other psychotic disorders. It may also be used off-label for managing acute agitation or aggression in psychiatric patients.

==Dosage and Administration==
The dosage of perazine varies depending on the patient's age, weight, and severity of symptoms. It is typically administered orally in tablet form, with dosing frequency ranging from once to several times daily. In some cases, intramuscular injection may be used for rapid symptom control.

==Side Effects==
Common side effects of perazine include drowsiness, dizziness, dry mouth, constipation, and blurred vision. It may also cause extrapyramidal symptoms such as tremors, muscle stiffness, and tardive dyskinesia, especially with long-term use or at higher doses.

==Precautions and Warnings==
Patients taking perazine should be monitored regularly for signs of movement disorders, neuroleptic malignant syndrome, and other serious adverse reactions. It is important to avoid abrupt discontinuation of the medication to prevent withdrawal symptoms or rebound psychosis.

==Contraindications==
Perazine is contraindicated in individuals with known hypersensitivity to phenothiazines or any of the components of the medication. It should also be used with caution in patients with a history of cardiovascular disease, seizures, or glaucoma.

==Interactions==
Perazine may interact with other medications, including central nervous system depressants, anticholinergic drugs, and certain antibiotics or antifungals. Concurrent use of alcohol or illicit drugs may potentiate its sedative effects and increase the risk of adverse reactions.

==Legal Status==
The legal status of perazine varies by country, but it is generally available by prescription only due to its potential for serious side effects and abuse liability.

==See Also==
*[[Phenothiazine]]
*[[Antipsychotic Medications]]
*[[Schizophrenia]]

==External links==
(List along order below)
* [https://de.wikipedia.org/wiki/Perazin (Wikipedia)]
* [https://www.gelbe-liste.de/wirkstoffe/Perazin_2412 (Gelbe-Liste)]
* [https://flexikon.doccheck.com/de/Perazin (DocCheck)]

==References==
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[[Category:Antipsychotic Medication]]
[[Category:Phenothiazines]]
[[Category:Proofread]]