View source for List of polysubstance combinations

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Poly drug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.

When combining euphoric stimulants and depressants, such as amphetamines and opioids, the sedative and stimulant effects may cancel out, allowing a higher dose of depressants. If the stimulant's effect wears off first, the user may be overwhelmed by depressant effects such as respiratory depression. These "speed-ball" combinations are also significantly more risky and addictive than either substance alone.<ref>"Speedballs often give stronger effects than either drug when taken alone due to drug synergy, and are a particularly hazardous mixture that can easily cause heart attack, respiratory arrest and death. When compared to single drugs, speedballs are more likely to lead to addiction, and users are more likely to relapse and also to overdose."

https://en.wikipedia.org/wiki/Speedball_(drug)</ref>

A study among treatment admissions found that it is more common for younger people to report polydrug drug use.<ref>"Polydrug Use Among Treatment Admissions: 1998." OAS Home: Alcohol, Tobacco & Drug Abuse and Mental Health Data from SAMHSA, Office of Applied Studies. Web. 29 Sept. 2011. [http://oas.samhsa.gov/2k1/polydrugTX/polydrugTX.htm]</ref>

==Common combinations==

{| class="wikitable sortable" border="1" style="font-size:smaller"
|-
!Drug 1!!Drug 2!!Drug 3!!Poly drug name<ref name="Telegraph">{{cite web|last1=Copping|first1=Jasper|title=Drug slang: what police must learn A to B|url=http://www.telegraph.co.uk/news/uknews/law-and-order/6519175/Drug-slang-what-police-must-learn-A-to-B.html|date=8 November 2009}}</ref>!!Intoxication name!!Comment
|-
|'''Any''' drug||[https://en.wikipedia.org/wiki/Black_tar_heroin Black tar heroin]|| ||[https://en.wikipedia.org/wiki/Whoonga Whoonga]|| ||Widespread use in South Africa
|-
|'''Any''' drug||[[Cannabis]]|| ||Amp joint|| ||Marijuana cigarette laced with some form of narcotic
|-
|'''Any''' drug||[[Nicotine]]|| ||Cooler|| ||A cigarette laced with a drug
|-
|'''Any''' [[depressant]]||Any [[stimulant]]|| ||Over and under|| ||Depressant effects are often used to gauge intoxication, causing one to overintoxicate themselves. If the stimulant effects wear off first, respiratory depression may occur.
|-
|'''Any''' [[pharmaceutical]]||Any [[pharmaceutical]]|| ||[https://en.wikipedia.org/wiki/Polypharmacy Polypharmacy]. Pharming, Pharm-hopping|| ||
|-
|'''Any''' synthetic [[opioid]]||Any [[Opioids|opioid]]|| ||[https://en.wikipedia.org/wiki/Gray_death Gray death]|| ||
|-
|[[8-chlorotheophylline]]||[[Diphenhydramine]]|| ||Nonproprietary name: [[Dimenhydrinate]]. Street slang: drama, dime" dime tabs, D-Q, substance D, d-house, and drams.<ref>{{Cite web|url=http://www.brighthub.com/science/medical/articles/51711.aspx|title=The Dangers of Dimenhydrinate Abuse|website=Bright Hub|access-date=2016-09-13}}</ref>||Dramatizing or "going a dime a dozen", a reference to the amount of Dramamine tablets generally necessary for a trip.<ref>{{Cite web|url=https://forum.grasscity.com/threads/dramamine.490953/|title=Dramamine|last=|first=|date=|website=Grasscity forums|publisher=|access-date=2016-09-13}}</ref>||
|-
|[[Alcohol]]||[[Caffeine]]|| ||[https://en.wikipedia.org/wiki/Caffeinated_alcoholic_drink Caffeinated alcoholic drink]|| ||Caffeine, a stimulant, masks some of the [[depressant]] effects of alcohol, may cause overintoxication.
|-
|[[Alcohol]]||[[Cannabis]]|| ||Herb and Al||Cross fading||
|-
|[[Alcohol]]||[[Cocaine]]|| ||Snow-coning|| ||Metabolized into a cocaethylene
|-
|[[Alcohol (drug)|Alcohol]]||[[Nicotine]]|| ||[https://en.wikipedia.org/wiki/Nicotini Nicotini]|| ||
|-
|[[Amphetamine]]||[[Cocaine]]|| ||Snow seals|| ||
|-
|[[Amphetamine]]
|[[Ketamine]]
|
|Ketamphetamine
|
|May increase blood pressure
|-
|''Banisteriopsis caapi''||[[Beta-Carboline|β-Carboline]]s containing plants (eg ''Peagnum harmala'')|| ||[[Ayahuasca]], [[changa]]|| ||
|-
|[[Caffeine]]||[[Cannabis]]|| ||Hippie-speedballing|| ||
|-
|[[Caffeine]]||[[Methamphetamine]]|| ||Biker's coffee, [https://en.wikipedia.org/wiki/Ya_ba Ya ba]|| ||Generally unnecessary and may increase strain on the heart, anxiety and physical discomfort.
|-
|[[Cannabis]]||[[Crack-cocaine]]|| ||Crack weed (less known: champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, splitting, thirty eight, turbo, wollie, yeola)||Cocoa puffs<ref>https://www.urbandictionary.com/define.php?term=cocoa+puffs</ref>||
|-
|[[Cannabis]]||[[Crack-cocaine]]||[[PCP]]||Jim Jones|| ||
|-
|[[Cannabis]]||[[DXM]]||[[Nicotine]]||Candy blunt|| ||Cannabis is commonly used to reduce the strong nausea from the onset and come-up of DXM. CBD inhibits the enzyme CYP2D6, responsible for metabolising DXM into Dextorphan, which is responsible for the more dissociative effects of DXM
|-
|[[Cannabis]]||[[Heroin]]|| ||Atom bomb, stuff|| ||
|-
|[[Cannabis]]||[[Heroin]] or [[opium]]|| ||A-bomb|| ||
|-
|[[Cannabis]]||[[Opium]]|| ||Buddha|| ||
|-
|[[Cannabis]]||[[PCP]]|| ||Killer weed (less known: clickums, donk, dust blunt, illies, illing, leak, love leaf, lovelies, parsley, zoom)|| ||
|-
|[[Cannabis]]||[[Nicotine]]|| ||[https://en.wikipedia.org/wiki/Blunt_(cannabis) Blunt], [https://en.wikipedia.org/wiki/Joint_(cannabis) joint], spliff||Stoned||A rolled marijuana cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with marijuana. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
|-
|[[THC]]||[[CBD]]|| ||Nonproprietary name: [https://en.wikipedia.org/wiki/Nabiximols Nabiximols]|| ||
|-
|[[Cocaine]]||[[Heroin]]|| ||Snowball, murder one, whiz bang||Snowballing||
|-
|[[Cocaine]]||[[Heroin]]||[[LSD]]||Frisco special<ref>https://www.urbandictionary.com/define.php?term=Frisco%20Special</ref>|| ||
|-
|[[Cocaine]]||[[Heroin]]||[[Nicotine]]||flamethrower, primos|| ||Cigarette laced with cocaine and heroin
|-
|[[Cocaine]]||[[Heroin]] or [[morphine]]|| ||[https://en.wikipedia.org/wiki/Speedball_(drug) Speedball], powerball||Speedballing, powerballing||Speedballing, powerballing is often used to describe intravenous use. The term can also be applied to use of pharmaceutical opioids, benzodiazepines or barbiturates along with stimulants.
|-
|[[Cocaine]]||[[Ketamine]]|| ||CK, Calvin Klein, Pony Snow|| ||
|-
|[[Cocaine]]||[[LSD]]|| ||Cracid (or outer limits)|| ||
|-
|[[Cocaine]]||[[Morphine]]|| ||C & M|| ||
|-
|[[Codeine]]||[[Glutethimide]]|| ||Pancakes and syrups|| ||Combination of glutethimide and codeine cough syrup
|-
|[[Codeine]]||[[Promethazine]]|| ||Medicines: Kefei and Procodin. Street slang: [https://en.wikipedia.org/wiki/Lean_(drug) Lean], also known as purple drank, and oil. Less known as: sizzurp, lean, syrup, drank, barre, purple jelly, Texas tea, dirty Sprite, and Tsikuni)|| ||
|-
|[[Crack-cocaine]]||[[Heroin]]|| ||Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar|| ||
|-
|[[Crack-cocaine]]||[[LSD]]|| ||Outerlimits|| ||
|-
|[[Crack-cocaine]]||[[Methamphetamine]]|| ||Fire, twisters|| ||
|-
|[[Crack-cocaine]]||[[PCP]]||[[Nicotine]]||Ozone|| ||PCP and crack cigarette
|-
|[[Crack-cocaine]]||[[PCP]]|| ||Missile basing, P-funk, space basing,<ref>https://www.urbandictionary.com/define.php?term=space-basing</ref> spaceball, space cadet, space dust, tragic magic|| ||
|-
|[[Crack-cocaine]]||[[Nicotine]]|| ||Coolie, crimmie, woolas|| ||A cigarette laced with crack
|-
|[[DMT]]||[[MAOIs]]|| ||[[Ayahuasca]], [[Pharmahuasca]]|| ||Ayahuasca is brewed using natural plant matter.

Pharmahuasca is a more pharmaceutical-style preparation of the psychoactive ingredients
|-
|[[DXM]]||[[LSD]]|| ||LSDXM|| ||
|-
|[[DXM]]||[[Psilocybin]] or [[psilocybin mushroom]]|| ||Cherry-bombing|| ||
|-
|[[GHB]]||[[Methamphetamine]]|| ||Cherry meth|| ||
|-
|[[Hashish]]||[[Atropa belladonna (botany)|''Atropa belladonna'']]|| ||Alamout Black Hash<ref name="Erowid">https://erowid.org/psychoactives/slang/</ref>|| ||Mixed
|-
|[[Hashish]]||[[LSD]]|| ||Royal Temple Ball|| ||The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
|-
|[[Hashish]]||[[Opium]]|| ||Black hash|| ||
|-
|[[Heroin]]||[[Morphine]]|| ||New Jack swing|| ||
|-
|[[LSD]]||[[Nitrous oxide]]|| ||Gasid|| ||
|-
|[[LSD]]||[[PCP]]|| ||Black acid|| ||
|-
|[[LSD]]||[[Psilocybin]] or [[psilocybin mushroom]]|| ||God's flesh|| ||
|-
|[[LSD]]||[[MDMA]]||[[2C-B]]||Ali Flip||Ali Flipping||Ali Flipping is a mix of a Candy Flip and a Nexus Flip.
|-
|-
|[[MDMA]]||[[2C-B]]|| ||Nexus flip, honey flip<ref>https://www.urbandictionary.com/define.php?term=Nexus%20flip</ref>||Nexus flipping, honey flipping||
|-
|[[MDMA]]||[[2C-E]]|| ||Sparkle flip<ref>https://www.urbandictionary.com/define.php?term=sparkle+flip</ref>||Sparkle flipping||
|-
|[[MDMA]]||[[2C-I]]|| ||Science flip||Science flipping||
|-
|[[MDMA]]||[[2C-T-7]]|| ||Lucky flip||Lucky flipping||
|-
|[[MDMA]]||[[Alcohol]]|| ||Tipsy flip||Tipsy flipping||
|-
|[[MDMA]]||[[Cocaine]]|| ||Sugar flip<ref>https://www.urbandictionary.com/define.php?term=sugar+flip</ref>||Sugar flipping||
|-
|[[MDMA]]||[[Cocaine]]||[[LSD]]||Candy-flip on a string||Candy-flipping on a string||
|-
|[[MDMA]]||[[DMT]]|| ||Shaman flip, time flip||Shaman flipping, time flipping||
|-
|[[MDMA]]||[[DXM]]|| ||Robo flip<ref>https://www.urbandictionary.com/define.php?term=Robo+Flipping</ref>||Robo flipping||
|-
|[[MDMA]]||[[GHB]]|| ||Gamma flip<ref>https://www.urbandictionary.com/define.php?term=Gamma-flipping</ref>||Gamma flipping||
|-
|[[MDMA]]||[[Ketamine]]|| ||Kitty flip<ref>https://www.urbandictionary.com/define.php?term=kitty+flipping</ref>||Kitty flipping||
|-
|[[MDMA]]||[[Ketamine]]||[[GHB]]||EKG. The "E" is for Ecstasy.|| ||
|-
|[[MDMA]]||[[LSD]]|| ||Candy flip<ref>https://www.urbandictionary.com/define.php?term=candy%20flip</ref>||Candy flipping||
|-
|[[MDMA]]||[[LSD]]||[[Psilocybin]] or [[psilocybin mushroom]]||Jedi flip, twilight flip<ref>https://www.urbandictionary.com/define.php?term=jedi+flipping</ref><ref>https://www.urbandictionary.com/define.php?term=twilight+flip</ref>||Jedi flipping, twilight flipping||
|-
|[[MDMA]]||[[MDEA]]|| ||Adam and Eve|| ||
|-
|[[MDMA]]||[[Mescaline]] or [[psychedelic cactus]]|| ||Love flip<ref>https://www.urbandictionary.com/define.php?term=love%20flip</ref>||Love flipping||
|-
|[[MDMA]]||[[Methadone]]|| ||Chocolate flip||Chocolate flipping||
|-
|[[MDMA]]||[[Methamphetamine]]|| ||Trailer flip||Trailer flipping||
|-
|[[MDMA]]||[[Nitrous oxide]]|| ||Nox|| ||
|-
|[[MDMA]]||[[Opiates]]|| ||Poppy flip||Poppy flipping||
|-
|[[MDMA]]||[[PCP]]|| ||Elephant flip<ref>https://www.urbandictionary.com/define.php?term=Elephant%20Flipping</ref>||Elephant flipping||
|-
|[[MDMA]]||[[Psilocybin]] or [[psilocybin mushroom]]|| ||Hippy flip, flower flip<ref>https://www.urbandictionary.com/define.php?term=Flower+Flipping</ref>)<ref>http://www.urbandictionary.com/define.php?term=hippy%20flipping</ref>||Hippy flipping, flower flipping||
|-
|[[MDMA]]||[[Psilocybin]] or [[psilocybin mushroom]]||[[Cocaine]]||Flower flip on a string, hippie flip on a string||Flower flipping on a string, hippie flipping on a string||
|-
|[[MDMA]]||[[Sildenafil]]|| ||Sextasy (or hammerheading)<ref>https://www.urbandictionary.com/define.php?term=sextacy</ref>|| ||
|-
|[[MDMA]]
|[[Diphenhydramine|DPH]]
|
|Nightmare flip
|Nightmare flipping
|
|-
|[[PCP]]||[[Nicotine]]|| ||Chipping|| ||
|-
|[[Psilocybin]]||Any MAOI|| ||Psilohuasca|| ||
|-
|[[Xylazine]]||[[Fentanyl]]|| ||Tranq, Tranq-dope, Sleep cut, Zombie|| ||Often associated with medical complications and deaths, provides excessive sedation with little euphoria.
|-
|[[DXM]]
|[[Diphenhydramine|DPH]]
|
|Counter flip
|Counter flipping
|The synergy of this combo is considered to be unique in that it does not simply combine the effects, but creates a unique experience altogether see [[DXM & DPH]]
|}

===2C-B + ketamine===
DM Turner:

*"Taking Ketamine while on 2C-B has produced some absolutely spectacular experiences. I've used this combination some 30-40 times and have never failed to hit the mark." "Another important benefit of combining Ketamine with 2C-B is that recall of the experience is significantly increased. Visiting this realm of cosmic fun and knowledge but coming back with only the faintest recollection of what one's experienced can be frustrating, and leave one feeling that something is missing. Such was a common feeling with much of my early Ketamine experimentation. But since I began using Ketamine with 2C-B, I find I can now access my memory at any time, and recall in a fair amount of detail many exotic and fascinating experiences."<ref>{{cite web|title=Erowid Online Books : "The Essential Psychedelic Guide" - Psychedelic Reality|url=https://erowid.org/library/books_online/essential_psychedelic_guide/cydelikspace.shtml|website=erowid.org}}</ref>
*"One problem I find with Ketamine is that the experience is difficult to bring back and reintegrate with routine reality. Memory of the experience is even difficult. Within hours after coming back, 99% of the experience is inaccessible to my current conscious mind. The Ketamme experience is so bizarre and otherworldly that a normal mind can't even conceive of experiencing in this manner. It feels as though some part of the mind protectively closes off access to the dimensions experienced on Ketamine. I've recently found a method that is proving effective at solving this problem. This is to take Ketamine while already high on 2C-B. This seems to provide a "bridge" between the ego or identity, and a state that is ego-less and without limitations." "I've found Ketamine to combine best with 2C-B This produces an enhanced K journey as well as reducing the negative effects during the recovery period. Limited experimentation with some rare synthetic phenethylamines, including 2CT7, 2CT2, and DOB, have also produced good results. I find no enhancement of the K journey when combining it with ecstasy, however, this does reduce the discomfort of the recovery period. Combining K with LSD produces an enhanced K journey, however the recovery period can be a serious drag."<ref>{{cite web|title=Erowid Online Books : "The Essential Psychedelic Guide" - Ketamine|url=https://erowid.org/library/books_online/essential_psychedelic_guide/ketamine.shtml|website=erowid.org}}</ref>

===2C-B + MDMA===
2C-B combined with MDMA is known as nexus flipping or honey flipping.

Alexander Shulgin: "Many of the reports that have come in over the years have mentioned the combination of MDMA and 2C-B. The most successful reports have followed a program in which the two drugs are not used at the same time, nor even too closely spaced. It appears that the optimum time for the 2C-B is at, or just before, the final baseline recovery of the MDMA. It is as if the mental and emotional discoveries can be mobilized, and something done about them. This combination has several enthusiastic advocates in the psychotherapy world, and should be the basis of careful research when these materials become legal, and accepted by the medical community."<ref>http://www.erowid.org/library/books_online/pihkal/pihkal020.shtml</ref>

==Dangerous interactions==
{{merge from|Dangerous combinations}}
{{main|Dangerous combinations}}

[[File:TripSit's Dangerous combination chart.png|400px|thumb|right|A useful chart from [https://tripsit.me/ TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.]]

The combos in this section is used to list cut drugs, drugs used to incapacitate victims, or even kill people. Never use them!

==See also==

*[[Talk:Substance lacing]]

==External links==

*[[wikipedia:Poly drug use|Poly drug use (Wikipedia)]]
**[https://en.wikipedia.org/wiki/Ayahuasca Ayahuasca (Wikipedia)]
**[https://en.wikipedia.org/wiki/Changa Changa (Wikipedia)]
**[https://en.wikipedia.org/wiki/Dimenhydrinate Dimenhydrinate (Wikipedia)]
**[https://en.wikipedia.org/wiki/Pharmahuasca Pharmahuasca (Wikipedia)]
*[https://erowid.org/psychoactives/slang/ Erowid: Drug Slang & Terminology Vault]
*[http://www.telegraph.co.uk/news/uknews/law-and-order/6519175/Drug-slang-what-police-must-learn-A-to-B.html Drug slang: what police must learn A to B - 3,000 slang words and phrases associated with illegal drugs]
*[http://recreationaldrugs.wikia.com/wiki/Polydrug_Terms Recreational Drug Wiki: Polydrug Terms]
*[https://www.reddit.com/r/Drugs/comments/gh0vq/dae_wonder_what_are_the_names_of_the_different/ Subreddit Drugs: DAE wonder what are the names of the different mdma flips?]

==References==
{{reflist}}

[[Category:Substance-related lists]]

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