Lysergamides

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Substitutive structure of a lysergamide

Lysergamides are amides of lysergic acid.

Ergoline refers to a class of compounds derived from alkaloids of a group of fungi known as ergot in the claviceps genus. These compounds typically have have strong psychedelic effects.

Chemistry

Lysergamides are polycyclic amides which have both phenethylamine and tryptamine groups embedded within their structure and a carboxamide group attached to carbon number eight. Varying the substituent attached to the nitrogen atoms has produced a variety of drugs with psychedelic effects as well as prescription drugs for treating headaches and inducing labor. Hydroxylation of the aromatic ring is one method of metabolizing lysergamides in humans and produces compounds with greater affinity to dopamine receptors.

Pharmacology

Main article: Serotonergic psychedelic

The psychedelic effects of lysergamides are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. Lysergamides are known to have affinity for a much greater variety of receptors than other psychedelic drugs.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

List of substituted lysergamides

Compound	RN1	RN2	R1	R6	Structure
1P-ETH-LAD	CH2CH3	CH2CH3	C=OCH2CH3	CH2CH3
1P-LSD	CH2CH3	CH2CH3	C=OCH2CH3	CH3
ALD-52	CH2CH3	CH2CH3	C=OCH3	CH3
AL-LAD	CH2CH3	CH2CH3	H	CH2CH=CH2
ETH-LAD	CH2CH3	CH2CH3	H	CH2CH3
LSA	H	H	H	CH3
LSD	CH2CH3	CH2CH3	H	CH3
LSH	CH(OH)CH3	H	H	CH3
LSM-775	CH2CH2O-	CH2CH2-	H	CH3
LSZ	CH(CH3)CH2-	CH(CH3)CH2-	H	CH3
PARGY-LAD	CH2CH3	CH2CH3	H	CH2C≡CH	170px
PRO-LAD	CH2CH3	CH2CH3	H	CH2CH2CH3

See also

• Responsible use
• Lysergamide (Wikipedia)
• LSD
• LSA
• Phenethylamine
• Tryptamine

References

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