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Template:Warning/Tizanidine
Tizanidine can induce dangerously low blood pressures when used in excessive doses [1] [2]
Care should be taken when taking high doses of tizanidine, even with an established tolerance. Users taking hallucinogenic doses should have a hypertensive agent available[3] or a supervisor present. Exercise extreme caution when attempting hallucinogenic doses.
- ↑ Johnson TR, Tobias JD. Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. J Child Neurol. 2000 Dec;15(12):818-9. doi: 10.1177/088307380001501211. PMID: 11198499.
- ↑ Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP. Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study. Clin Pharmacol Ther. 2019 Mar;105(3):703-709. doi: 10.1002/cpt.1233. Epub 2018 Oct 18. PMID: 30223305; PMCID: PMC6379114.
- ↑ Sharma S, Hashmi MF, Bhattacharya PT. Hypotension. [Updated 2022 Feb 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.