Talk:Dextrorphan
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Most of the first paragraph should be moved to a chemistry section. Please discuss the substance and noteworthy facts in the leading paragraphs. |
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| Dextrorphan | |||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||
| Common names | DXO | ||||||||||||||||||||
| Substitutive name | Dextrorphan | ||||||||||||||||||||
| Systematic name | (+)-17-methyl-9a,13a,14a-morphinan-3-ol | ||||||||||||||||||||
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| Psychoactive class | Dissociative | ||||||||||||||||||||
| Chemical class | Morphinan | ||||||||||||||||||||
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Dextrorphan (also known as DXO) is the main active metabolite of dextromethorphan (DXM). DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the subjective effects experienced when active doses of DXM are consumed.[1]
Pharmacology
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[2] One user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.[3]
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
- Appetite suppression
- Changes in felt bodily form
- Gustatory hallucinations
- Itchiness - This effect has become subsequently known as "robo-itch" and though relatively common there are many users who never experience this particular effect while some individuals can experience it quite intensely.
- Muscle spasms
- Motor control loss
- Pain relief
- Perception of decreased weight
- Physical autonomy
- Spatial disorientation
- Tactile disconnection
- Tactile suppression
Cognitive effects
- Amnesia
- Conceptual thinking
- Consciousness disconnection
- Creativity enhancement
- Déjà vu
- Depersonalization
- Derealization
- Disinhibition
- Existential self-realization
- Immersion enhancement
- Increased music appreciation
- Information processing suppression
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Thought deceleration
- Time distortion
- Unity and interconnectedness
See also
References
- ↑ Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016)[1]
- ↑ Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [2]
- ↑ "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [3]