Modulator

Potentiators are a class of substance that can be used to enhance a users sensitivity to another substance, although they are also known to potentially cause effects on their own by interacting with endogenously produced substances. A well known example of the use of potentiators in psychonautics is the inclusion of Harmala alkaloids in Ayahuasca -a shamanic beverage introduced to modern culture through the indigenous peoples of Amazonian Peru. Since then potentiators have begun to emerge as a novel tool when used in conjunction with certain psychoactives, and as such many new combinations have sprung up in recent years.

Specific Compounds Nonselective MAO-A/MAO-B inhibitors Hydrazines Isocarboxazid (Marplan) Nialamide (Niamid) Phenelzine (Nardil, Nardelzine) Hydracarbazine Benmoxin (Nerusil, Neuralex) Iproclozide (Sursum) Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida) (discontinued worldwide except for France) Mebanazine (Actomol) Octamoxin (Ximaol, Nimaol) Pheniprazine (Catron) Phenoxypropazine (Drazine) Pivalylbenzhydrazine (Tersavid) Safrazine (Safra) Other Tranylcypromine (Parnate, Jatrosom) Caroxazone (Surodil, Timostenil) Methylene blue Linezolid Selective MAO-A inhibitors Harmala alkaloids Harmine Harmaline Other Bifemelane (Alnert, Celeport) Moclobemide (Aurorix, Manerix) Pirlindole (Pirazidol) Toloxatone (Humoryl) Minaprine (Cantor) Selective MAO-B inhibitors Hordenine Rasagiline (Azilect) Selegiline (Deprenyl, Eldepryl, Emsam, Zelapar)

Botanical Sources Citrus × paradisi (Grapefruit) Peganum harmala (Syrian rue) Banisteriopsis caapi (Ayahuasca vine) Hordeum vulgare L. (Barley) Echinopsis candicans Panicum miliaceum (Pproso Millet) Sorghum vulgare (Sorghum ) Ariocarpus fissuratus (Chautle) Passiflora incarnata (Passion Flower)